V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog (FOS)

[Edit]

Cfos; C-Fos; G0S7; Proto-oncogene c-Fos; G0/G1 Switch Regulatory Protein 7; Cellular oncogene fos

V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog (FOS)
In molecular biology, c-Fos is a cellular proto-oncogene belonging to the immediate early gene family of transcription factors. c-Fos has a leucine-zipper DNA binding domain, and a transactivation domain at the C-terminus. Transcription of c-Fos is upregulated in response to many extracellular signals, e.g. growth factors. Additionally, phosphorylation by MAPK, PKA, PKC or cdc2 alters the activity and stability of c-Fos. Members of the Fos family dimerise with C-Jun to form the AP-1 transcription factor, which upregulates transcription of a diverse range of genes involved in everything from proliferation and differentiation to defense against invasion and cell damage. The viral homologue of c-Fos, v-Fos, is found in the retrovirus Finkel–Biskis–Jinkins murine osteogenic sarcoma virus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB291Hu01 Recombinant V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog (FOS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB291Hu01 Polyclonal Antibody to V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog (FOS) WB; IHC; ICC; IP.
MAB291Hu22 Monoclonal Antibody to V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog (FOS) WB; IHC; ICC; IP.
Assay Kits SEB291Hu ELISA Kit for V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog (FOS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB291Mu01 Recombinant V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog (FOS) Positive Control; Immunogen; SDS-PAGE; WB.
RPB291Mu02 Recombinant V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog (FOS) Positive Control; Immunogen; SDS-PAGE; WB.
EPB291Mu61 Eukaryotic V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog (FOS) Positive Control; Immunogen; SDS-PAGE; WB.
APB291Mu61 Active V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog (FOS) Cell culture; Activity Assays.
RPB291Mu03 Recombinant V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog (FOS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB291Mu01 Polyclonal Antibody to V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog (FOS) WB; IHC; ICC; IP.
PAB291Mu02 Polyclonal Antibody to V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog (FOS) WB; IHC; ICC; IP.
Assay Kits SEB291Mu ELISA Kit for V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog (FOS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB291Ra01 Recombinant V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog (FOS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB291Ra01 Polyclonal Antibody to V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog (FOS) WB; IHC; ICC; IP.
MAB291Ra21 Monoclonal Antibody to V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog (FOS) WB; IHC; ICC; IP.
Assay Kits SEB291Ra ELISA Kit for V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog (FOS) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein."Proc. Natl. Acad. Sci. U.S.A. 80:3183-3187(1983) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Retrovirus-mediated gene transfer of a human c-fos cDNA into mouse bone marrow stromal cells."Oncogene 6:2155-2160(1991) [PubMed] [Europe PMC] [Abstract]
  6. "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers."Genes Dev. 3:2083-2090(1989) [PubMed] [Europe PMC] [Abstract]
  7. ErratumGenes Dev. 4:682-682(1990)
  8. "The basic region of Fos mediates specific DNA binding."EMBO J. 8:3833-3841(1989) [PubMed] [Europe PMC] [Abstract]
  9. "The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells."EMBO J. 14:5048-5059(1995) [PubMed] [Europe PMC] [Abstract]
  10. "Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription."Nature 394:909-913(1998) [PubMed] [Europe PMC] [Abstract]
  11. "Molecular interpretation of ERK signal duration by immediate early gene products."Nat. Cell Biol. 4:556-564(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation."Mol. Cell. Biol. 25:6964-6979(2005) [PubMed] [Europe PMC] [Abstract]
  13. "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation."Nucleic Acids Res. 35:E109-E109(2007) [PubMed] [Europe PMC] [Abstract]
  15. "N-Terminal c-Fos tyrosine phosphorylation regulates c-Fos/ER association and c-Fos-dependent phospholipid synthesis activation."Oncogene 26:3551-3558(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "The kinase c-Src and the phosphatase TC45 coordinately regulate c-Fos tyrosine phosphorylation and c-Fos phospholipid synthesis activation capacity."Oncogene 31:3381-3391(2012) [PubMed] [Europe PMC] [Abstract]
  18. "Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA."Nature 373:257-261(1995) [PubMed] [Europe PMC] [Abstract]