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Adrenergic Receptor Alpha 1A (ADRa1A)

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ADR-A1A; ADRA1-A; ADRA1C; ADRA1L1; Alpha1AAR; Alpha 1a-Adrenoceptor

Adrenergic Receptor Alpha 1A (ADRa1A)
CCC B298
HGNC 277
MGI 104773
PubMed 21519279
RGD 2055
UniProt P35348
Wiki ADRA1A

The alpha 1c- Adrenergic Receptor, also known as alpha 1a-adrenoceptor, is activated by epinephrine and norepinephrine. This receptor mediates calcium release upon ligand binding. The alpha 1-c adrenoceptor is one of three subtypes of alpha 1-adrenergic receptor (alpha 1 c/a, alpha 1b, and alpha 1d). The alpha 1c receptor couples to phospholipase C via a GTP-binding protein insensitive to pertussis toxin. Three isoforms are generated by alternative splicing. However, the corresponding isoforms of the protein have similar ligand-binding properties, effector coupling, and tissue distribution. Expression of this receptor has been reported in prostate, liver, kidney, heart, brain, spinal cord, bladder, and various blood vessels. ESTs have been isolated from liver and testis libraries.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB298Hu01 Recombinant Adrenergic Receptor Alpha 1A (ADRa1A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB298Hu01 Polyclonal Antibody to Adrenergic Receptor Alpha 1A (ADRa1A) WB; IHC; ICC; IP.
MAB298Hu22 Monoclonal Antibody to Adrenergic Receptor Alpha 1A (ADRa1A) WB; IHC; ICC; IP.
Assay Kits SEB298Hu ELISA Kit for Adrenergic Receptor Alpha 1A (ADRa1A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adrenergic Receptor Alpha 1A (ADRa1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adrenergic Receptor Alpha 1A (ADRa1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adrenergic Receptor Alpha 1A (ADRa1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adrenergic Receptor Alpha 1A (ADRa1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adrenergic Receptor Alpha 1A (ADRa1A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adrenergic Receptor Alpha 1A (ADRa1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adrenergic Receptor Alpha 1A (ADRa1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adrenergic Receptor Alpha 1A (ADRa1A) Polyclonal Antibody Customized Service Offer
Assay Kits SEB298Ra ELISA Kit for Adrenergic Receptor Alpha 1A (ADRa1A) Enzyme-linked immunosorbent assay for Antigen Detection.
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  3. "The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype."Mol. Pharmacol. 45:703-708(1994) [PubMed] [Europe PMC] [Abstract]
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  12. "Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes."Circ. Res. 103:992-1000(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Nuclear localization drives alpha1-adrenergic receptor oligomerization and signaling in cardiac myocytes."Cell. Signal. 24:794-802(2012) [PubMed] [Europe PMC] [Abstract]
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  16. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]