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Agouti Related Protein (AGRP)

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AGRT; ASIP2; ART; Agouti-Related Peptide

Agouti Related Protein (AGRP)
CCC B302
HGNC 330
MGI 892013
PubMed 18470724
RGD 2068
UniProt O00253
Wiki AGRP

Agouti-related protein is a neuropeptide produced in the brain (in the arcuate nucleus of the hypothalamus) by the AgRP/NPY neuron that increases appetite and decreases metabolism and energy expenditure. It is one of the most potent and long-lasting of appetite stimulators. Understanding the role AgRP plays in weight gain may assist in developing pharmaceutical models for treating obesity. It was identified independently by two teams based on sequence similarity with Agouti signalling peptide, a protein synthetized in the skin that controls coat color.The appetite stimulating effects of AgRP are inhibited by the hormone leptin. Adipocytes secrete leptin in response to food intake. This hormone acts in the arcuate nucleus and inhibits the AgRP/NPY neuron from releasing orexigenic peptides.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB302Hu01 Recombinant Agouti Related Protein (AGRP) Positive Control; Immunogen; SDS-PAGE; WB.
EPB302Hu61 Eukaryotic Agouti Related Protein (AGRP) Positive Control; Immunogen; SDS-PAGE; WB.
APB302Hu61 Active Agouti Related Protein (AGRP) Cell culture; Activity Assays.
Antibodies PAB302Hu01 Polyclonal Antibody to Agouti Related Protein (AGRP) WB,IHC
MAB302Hu22 Monoclonal Antibody to Agouti Related Protein (AGRP) WB; IHC; ICC; IP.
Assay Kits SEB302Hu ELISA Kit for Agouti Related Protein (AGRP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB302Mu01 Recombinant Agouti Related Protein (AGRP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB302Mu02 Recombinant Agouti Related Protein (AGRP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB302Mu01 Polyclonal Antibody to Agouti Related Protein (AGRP) WB; IHC; ICC; IP.
LAB302Mu71 Biotin-Linked Polyclonal Antibody to Agouti Related Protein (AGRP) WB; IHC; ICC.
PAB302Mu02 Polyclonal Antibody to Agouti Related Protein (AGRP) WB; IHC; ICC; IP.
Assay Kits SEB302Mu ELISA Kit for Agouti Related Protein (AGRP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB302Ra01 Recombinant Agouti Related Protein (AGRP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB302Ra02 Recombinant Agouti Related Protein (AGRP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB302Ra01 Polyclonal Antibody to Agouti Related Protein (AGRP) WB; IHC; ICC; IP.
PAB302Ra02 Polyclonal Antibody to Agouti Related Protein (AGRP) WB; IHC; ICC; IP.
LAB302Ra71 Biotin-Linked Polyclonal Antibody to Agouti Related Protein (AGRP) WB; IHC; ICC.
Assay Kits SEB302Ra ELISA Kit for Agouti Related Protein (AGRP) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice."Genes Dev. 11:593-602(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein."Science 278:135-138(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The gene structure and minimal promoter of the human agouti related protein."Gene 277:231-238(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Association between an agouti-related protein gene polymorphism and anorexia nervosa."Mol. Psychiatry 6:325-328(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Determination of disulfide structure in agouti-related protein (AGRP) by stepwise reduction and alkylation."Biochemistry 37:12172-12177(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of Agouti-related protein binding to melanocortin receptors."Mol. Endocrinol. 13:148-155(1999) [PubMed] [Europe PMC] [Abstract]
  8. "AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor."Mol. Endocrinol. 15:164-171(2001) [PubMed] [Europe PMC] [Abstract]
  9. "The natural inverse agonist agouti-related protein induces arrestin-mediated endocytosis of melanocortin-3 and -4 receptors."J. Biol. Chem. 281:37447-37456(2006) [PubMed] [Europe PMC] [Abstract]
  10. "NMR structure of a minimized human agouti related protein prepared by total chemical synthesis."FEBS Lett. 451:125-131(1999) [PubMed] [Europe PMC] [Abstract]
  11. "High-resolution NMR structure of the chemically-synthesized melanocortin receptor binding domain AGRP(87-132) of the agouti-related protein."Biochemistry 40:15520-15527(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Design, pharmacology, and NMR structure of a minimized cystine knot with agouti-related protein activity."Biochemistry 41:7565-7572(2002) [PubMed] [Europe PMC] [Abstract]
  13. "A polymorphism in the human agouti-related protein is associated with late-onset obesity."J. Clin. Endocrinol. Metab. 87:4198-4202(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Functional analysis of the Ala67Thr polymorphism in agouti related protein associated with anorexia nervosa and leanness."Biochem. Pharmacol. 70:308-316(2005) [PubMed] [Europe PMC] [Abstract]