Integrin Alpha 1 (ITGa1)

[Edit]

CD49-A; CD49a; ITG-A1; VLA1; CD49 antigen-like family member A; Laminin and collagen receptor

Integrin Alpha 1 (ITGa1)
CD49a encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.
The integrin alpha-1 chain associates with the beta-1 chain (ITGB1) to form a heterodimer that functions as a dual laminin/collagen receptor in neural cells and hematopoietic cells. It has a role in cell attachment and neurite outgrowth on laminin and collagen as well as in peripheral nerve regeneration

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB313Hu01 Recombinant Integrin Alpha 1 (ITGa1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB313Hu01 Polyclonal Antibody to Integrin Alpha 1 (ITGa1) WB
MAB313Hu22 Monoclonal Antibody to Integrin Alpha 1 (ITGa1) WB; IHC; ICC; IP.
Assay Kits SEB313Hu ELISA Kit for Integrin Alpha 1 (ITGa1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB313Mu01 Recombinant Integrin Alpha 1 (ITGa1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB313Mu02 Recombinant Integrin Alpha 1 (ITGa1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB313Mu01 Polyclonal Antibody to Integrin Alpha 1 (ITGa1) WB; IHC; ICC; IP.
PAB313Mu02 Polyclonal Antibody to Integrin Alpha 1 (ITGa1) WB; IHC; ICC; IP.
Assay Kits SEB313Mu ELISA Kit for Integrin Alpha 1 (ITGa1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB313Ra01 Recombinant Integrin Alpha 1 (ITGa1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB313Ra01 Polyclonal Antibody to Integrin Alpha 1 (ITGa1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Integrin Alpha 1 (ITGa1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Alpha 1 (ITGa1) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB313Ga01 Recombinant Integrin Alpha 1 (ITGa1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB313Ga01 Polyclonal Antibody to Integrin Alpha 1 (ITGa1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Integrin Alpha 1 (ITGa1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Alpha 1 (ITGa1) ELISA Kit Customized Service Offer
  1. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Expression of native and truncated forms of the human integrin alpha 1 subunit."J. Biol. Chem. 268:2989-2996(1993) [PubMed] [Europe PMC] [Abstract]
  4. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP."Nat. Cell Biol. 7:78-85(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins."J. Cell Biol. 173:767-780(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, alpha(1)beta(1) integrin and Staphylococcus aureus cna MSCRAMM."J. Biol. Chem. 274:24906-24913(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Jararhagin-derived RKKH peptides induce structural changes in alpha1I domain of human integrin alpha1beta1."J. Biol. Chem. 279:7962-7970(2004) [PubMed] [Europe PMC] [Abstract]