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Cyclic AMP Response Element Binding Protein (CREB)

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CREB1; CAMP Responsive Element Binding Protein 1

Cyclic AMP Response Element Binding Protein (CREB)
CCC B318
HGNC 2345
MGI 88494
PubMed 16207717
RGD 620218
UniProt P16220
Wiki CREB
CREB (cAMP response element-binding) proteins are transcription factors which bind to certain sequences called cAMP response elements (CRE) in DNA and thereby increase or decrease the transcription of certain genes. CREB is highly related (in structure and function) to CREM (cAMP response element modulator) and ATF-1 (activating transcription factor-1) proteins. CREB proteins are active in many animals, including humans.
The typical (somewhat simplified) sequence of events is as follows: a signal arrives at the cell surface, activates the corresponding receptor, which leads to the production of a second messenger such as cAMP or Ca2 , which in turn activates a protein kinase. This protein kinase moves to the cell nucleus, where it activates a CREB protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB318Hu01 Recombinant Cyclic AMP Response Element Binding Protein (CREB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB318Hu01 Polyclonal Antibody to Cyclic AMP Response Element Binding Protein (CREB) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cyclic AMP Response Element Binding Protein (CREB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclic AMP Response Element Binding Protein (CREB) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclic AMP Response Element Binding Protein (CREB) Recombinant Protein Customized Service Offer
Antibodies PAB318Mu01 Polyclonal Antibody to Cyclic AMP Response Element Binding Protein (CREB) WB; IHC; ICC; IP.
Assay Kits SEB318Mu ELISA Kit for Cyclic AMP Response Element Binding Protein (CREB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclic AMP Response Element Binding Protein (CREB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclic AMP Response Element Binding Protein (CREB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclic AMP Response Element Binding Protein (CREB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclic AMP Response Element Binding Protein (CREB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclic AMP Response Element Binding Protein (CREB) ELISA Kit Customized Service Offer
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  9. "HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions."Science 252:842-844(1991) [PubMed] [Europe PMC] [Abstract]
  10. "Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction."Proc. Natl. Acad. Sci. U.S.A. 89:7070-7074(1992) [PubMed] [Europe PMC] [Abstract]
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  12. "Transcriptional activation of egr-1 by granulocyte-macrophage colony-stimulating factor but not interleukin 3 requires phosphorylation of cAMP response element-binding protein (CREB) on serine 133."J. Biol. Chem. 270:15979-15983(1995) [PubMed] [Europe PMC] [Abstract]
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  18. "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector."Cell 119:61-74(2004) [PubMed] [Europe PMC] [Abstract]
  19. "A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription."Cell 123:833-847(2005) [PubMed] [Europe PMC] [Abstract]
  20. "Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB."FEBS Lett. 579:1534-1538(2005) [PubMed] [Europe PMC] [Abstract]
  21. "PGC-1-related coactivator: immediate early expression and characterization of a CREB/NRF-1 binding domain associated with cytochrome c promoter occupancy and respiratory growth."Mol. Cell. Biol. 26:7409-7419(2006) [PubMed] [Europe PMC] [Abstract]
  22. "EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma."Genes Chromosomes Cancer 46:1051-1060(2007) [PubMed] [Europe PMC] [Abstract]
  23. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  24. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  25. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  26. "Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271."Mol. Biol. Cell 21:2966-2974(2010) [PubMed] [Europe PMC] [Abstract]
  27. "TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex."J. Cell Sci. 124:252-260(2011) [PubMed] [Europe PMC] [Abstract]
  28. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  29. "A p.D116G mutation in CREB1 leads to novel multiple malformation syndrome resembling CrebA knockout mouse."Hum. Mutat. 33:651-654(2012) [PubMed] [Europe PMC] [Abstract]
  30. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]