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Focal Adhesion Kinase (FAK)

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PTK2; FADK; FAK1; Pp125FAK; PPP1R71; Protein Tyrosine Kinase 2; Focal adhesion kinase-related nonkinase; Protein phosphatase 1 regulatory subunit 71

Focal Adhesion Kinase (FAK)
CCC B333
HGNC 9611
MGI 95481
PubMed 15688067
RGD 3443
UniProt Q05397
Wiki PTK2

PTK2 is a focal adhesion-associated protein kinase involved in cellular adhesion and spreading processes. It has been shown that when FAK was blocked, breast cancer cells became less metastastic due to decreased mobility.FAK is a 125 Kd protein that is recruited as a participant in focal adhesion dynamics between cells and has a role in motility and cell survival. FAK is a highly conserved, non-receptor tyrosine kinase originally identified as a substrate for the oncogene protein tyrosine kinase v-src. This cytosolic kinase has been implicated in diverse cellular roles including cell locomotion, mitogen response and cell survival. FAK is typically located at structures known as focal adhesions, these are multi-protein structures that link the extracellular matrix (ECM) to the cytoplasmic cytoskeleton.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB333Hu01 Recombinant Focal Adhesion Kinase (FAK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB333Hu01 Polyclonal Antibody to Focal Adhesion Kinase (FAK) WB,IHC
MAB333Hu21 Monoclonal Antibody to Focal Adhesion Kinase (FAK) WB; IHC; ICC; IP.
MAB333Hu22 Monoclonal Antibody to Focal Adhesion Kinase (FAK) WB; IHC; ICC; IP.
MAB333Hu23 Monoclonal Antibody to Focal Adhesion Kinase (FAK) WB; IHC; ICC; IP.
MAB333Hu24 Monoclonal Antibody to Focal Adhesion Kinase (FAK) WB; IHC; ICC; IP.
Assay Kits SEB333Hu ELISA Kit for Focal Adhesion Kinase (FAK) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Focal Adhesion Kinase (FAK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Focal Adhesion Kinase (FAK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Focal Adhesion Kinase (FAK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Focal Adhesion Kinase (FAK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Focal Adhesion Kinase (FAK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB333Ra01 Recombinant Focal Adhesion Kinase (FAK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB333Ra01 Polyclonal Antibody to Focal Adhesion Kinase (FAK) WB; IHC; ICC; IP.
MAB333Ra21 Monoclonal Antibody to Focal Adhesion Kinase (FAK) WB; IHC; ICC; IP.
Assay Kits SEB333Ra ELISA Kit for Focal Adhesion Kinase (FAK) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Focal Adhesion Kinase (FAK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Focal Adhesion Kinase (FAK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Focal Adhesion Kinase (FAK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Focal Adhesion Kinase (FAK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Focal Adhesion Kinase (FAK) ELISA Kit Customized Service Offer
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  29. "A novel Cas family member, HEPL, regulates FAK and cell spreading."Mol. Biol. Cell 19:1627-1636(2008) [PubMed] [Europe PMC] [Abstract]
  30. "Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation."Mol. Cell 29:9-22(2008) [PubMed] [Europe PMC] [Abstract]
  31. "Regulation of estrogen rapid signaling through arginine methylation by PRMT1."Mol. Cell 31:212-221(2008) [PubMed] [Europe PMC] [Abstract]
  32. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  33. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
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  44. "Downregulation of FAK-related non-kinase mediates the migratory phenotype of human fibrotic lung fibroblasts."Exp. Cell Res. 316:1600-1609(2010) [PubMed] [Europe PMC] [Abstract]
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  46. "CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer."Nat. Immunol. 11:155-161(2010) [PubMed] [Europe PMC] [Abstract]
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  49. "Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism."J. Biol. Chem. 286:17292-17302(2011) [PubMed] [Europe PMC] [Abstract]
  50. "A novel splice variant of calcium and integrin-binding protein 1 mediates protein kinase D2-stimulated tumour growth by regulating angiogenesis."Oncogene 33:1167-1180(2014) [PubMed] [Europe PMC] [Abstract]
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  60. "Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer."IUBMB Life 62:268-276(2010) [PubMed] [Europe PMC] [Abstract]
  61. "Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions."J. Cell Sci. 123:1007-1013(2010) [PubMed] [Europe PMC] [Abstract]
  62. "Focal adhesion kinase: exploring Fak structure to gain insight into function."Int. Rev. Cell Mol. Biol. 288:185-225(2011) [PubMed] [Europe PMC] [Abstract]
  63. "MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression."J. Cell Biol. 200:773-787(2013) [PubMed] [Europe PMC] [Abstract]
  64. "The structural basis of localization and signaling by the focal adhesion targeting domain."Structure 10:319-327(2002) [PubMed] [Europe PMC] [Abstract]
  65. "Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography."Structure 10:1659-1667(2002) [PubMed] [Europe PMC] [Abstract]
  66. "Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain."Structure 11:1207-1217(2003) [PubMed] [Europe PMC] [Abstract]
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