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Actin Alpha 1, Cardiac Muscle (ACTC1)

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ACTC; CMD1R; CMD1-R; ACT-a1

Actin Alpha 1, Cardiac Muscle (ACTC1)
CCC B341
HGNC 143
MGI 87905
PubMed 24461919
RGD 2026
UniProt P68032
Wiki ACTC1
Actin, alpha cardiac muscle 1 is a protein encoded by the ACTC1 gene.Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others.
The protein encoded by this gene belongs to the actin family which is composed of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB341Hu01 Recombinant Actin Alpha 1, Cardiac Muscle (ACTC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB341Hu51 Polyclonal Antibody to Actin Alpha 1, Cardiac Muscle (ACTC1) WB; IHC; ICC; IP.
PAB341Hu01 Polyclonal Antibody to Actin Alpha 1, Cardiac Muscle (ACTC1) WB; IHC; ICC; IP; FCM
CAB341Hu22 Anti-Actin Alpha 1, Cardiac Muscle (ACTC1) Monoclonal Antibody Loading Control of WB.
CAB341Hu01 Anti-Actin Alpha 1, Cardiac Muscle (ACTC1) Polyclonal Antibody Loading Control of WB.
MAB341Hu21 Monoclonal Antibody to Actin Alpha 1, Cardiac Muscle (ACTC1) WB; IHC; ICC; IP.
MAB341Hu22 Monoclonal Antibody to Actin Alpha 1, Cardiac Muscle (ACTC1) WB; IHC; ICC; IP.
MAB341Hu23 Monoclonal Antibody to Actin Alpha 1, Cardiac Muscle (ACTC1) WB; IHC.
MAB341Hu24 Monoclonal Antibody to Actin Alpha 1, Cardiac Muscle (ACTC1) WB; IHC; ICC; IP.
MAB341Hu25 Monoclonal Antibody to Actin Alpha 1, Cardiac Muscle (ACTC1) WB; IHC; ICC; IP.
MAB341Hu26 Monoclonal Antibody to Actin Alpha 1, Cardiac Muscle (ACTC1) WB; IHC; ICC; IP.
MAB341Hu27 Monoclonal Antibody to Actin Alpha 1, Cardiac Muscle (ACTC1) WB; IHC; ICC; IP.
MAB341Hu29 Monoclonal Antibody to Actin Alpha 1, Cardiac Muscle (ACTC1) WB; IHC; ICC; IP.
Assay Kits AEB341Hu ELISA Kit for Anti-Actin Alpha 1, Cardiac Muscle Antibody (Anti-ACTC1) Enzyme-linked immunosorbent assay for Antibody Detection.
SEB341Hu ELISA Kit for Actin Alpha 1, Cardiac Muscle (ACTC1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Actin Alpha 1, Cardiac Muscle (ACTC1) Recombinant Protein Customized Service Offer
Antibodies PAB341Mu51 Polyclonal Antibody to Actin Alpha 1, Cardiac Muscle (ACTC1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Actin Alpha 1, Cardiac Muscle (ACTC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Actin Alpha 1, Cardiac Muscle (ACTC1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Actin Alpha 1, Cardiac Muscle (ACTC1) Recombinant Protein Customized Service Offer
Antibodies PAB341Ra51 Polyclonal Antibody to Actin Alpha 1, Cardiac Muscle (ACTC1) WB; IHC; ICC; IP.
Assay Kits AEB341Ra ELISA Kit for Anti-Actin Alpha 1, Cardiac Muscle Antibody (Anti-ACTC1) Enzyme-linked immunosorbent assay for Antibody Detection.
SEB341Ra ELISA Kit for Actin Alpha 1, Cardiac Muscle (ACTC1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular structure and evolutionary origin of human cardiac muscle actin gene."Proc. Natl. Acad. Sci. U.S.A. 79:5901-5905(1982) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "ALKBH4-dependent demethylation of actin regulates actomyosin dynamics."Nat. Commun. 4:1832-1832(2013) [PubMed] [Europe PMC] [Abstract]
  4. "Actin mutations in dilated cardiomyopathy, a heritable form of heart failure."Science 280:750-752(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Alpha-cardiac actin is a novel disease gene in familial hypertrophic cardiomyopathy."J. Clin. Invest. 103:R39-R43(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Inherited and de novo mutations in the cardiac actin gene cause hypertrophic cardiomyopathy."J. Mol. Cell. Cardiol. 32:1687-1694(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Clinical and genetic characteristics of alpha cardiac actin gene mutations in hypertrophic cardiomyopathy."J. Med. Genet. 41:E10-E10(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Alpha-cardiac actin mutations produce atrial septal defects."Hum. Mol. Genet. 17:256-265(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Shared genetic causes of cardiac hypertrophy in children and adults."N. Engl. J. Med. 358:1899-1908(2008) [PubMed] [Europe PMC] [Abstract]