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Activating Transcription Factor 1 (ATF1)

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EWS-ATF1; FUS/ATF-1; TREB36; Cyclic AMP-Dependent Transcription Factor

Activating Transcription Factor 1 (ATF1)
CCC B346
HGNC 783
MGI 1298366
PubMed 12957907
RGD 1307360
UniProt P18846
Wiki ATF1

This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP(basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation.

Activating Transcription Factor 1 binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. 

Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB346Hu01 Recombinant Activating Transcription Factor 1 (ATF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB346Hu01 Polyclonal Antibody to Activating Transcription Factor 1 (ATF1) WB; ICC; IHC-P; IHC-F; ELISA.
Assay Kits SEB346Hu ELISA Kit for Activating Transcription Factor 1 (ATF1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB346Mu01 Recombinant Activating Transcription Factor 1 (ATF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB346Mu01 Polyclonal Antibody to Activating Transcription Factor 1 (ATF1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Activating Transcription Factor 1 (ATF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Activating Transcription Factor 1 (ATF1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB346Ra01 Recombinant Activating Transcription Factor 1 (ATF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB346Ra01 Polyclonal Antibody to Activating Transcription Factor 1 (ATF1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Activating Transcription Factor 1 (ATF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Activating Transcription Factor 1 (ATF1) ELISA Kit Customized Service Offer
  1. "Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain."EMBO J. 9:2537-2542(1990) [PubMed] [Europe PMC] [Abstract]
  2. "The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A."J. Biol. Chem. 266:18431-18434(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers."Genes Dev. 3:2083-2090(1989) [PubMed] [Europe PMC] [Abstract]
  7. ErratumGenes Dev. 4:682-682(1990)
  8. "Genetic characterization of angiomatoid fibrous histiocytoma identifies fusion of the FUS and ATF-1 genes induced by a chromosomal translocation involving bands 12q13 and 16p11."Cancer Genet. Cytogenet. 121:109-116(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Regulation of activating transcription factor-1 and the cAMP response element-binding protein by Ca2+/calmodulin-dependent protein kinases type I, II, and IV."J. Biol. Chem. 271:3066-3073(1996) [PubMed] [Europe PMC] [Abstract]
  10. "Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma."Genes Chromosomes Cancer 44:97-102(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation."Cancer Res. 68:7650-7660(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress."J. Cell Sci. 123:3863-3871(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]