Small Nuclear Ribonucleoprotein Polypeptide C (SNRPC)

The C polypeptide is one of the specific protein constituents of the U1 snRNP (small nuclear ribonucleoprotein) particle. See SNRPA. Patients with connective tissue diseases often produce autoantibodies against snRNP particles. By screening human expression libraries with anti-RNP sera, both Yamamoto et al. (1988) and Sillekens et al. (1988) isolated cDNAs encoding SNRPC.

Using Northern blot hybridization, Yamamoto et al. (1988) determined that SNRPC is expressed as an approximately 0.8-kb mRNA. Antibodies against SNRPC stained the nuclei of HeLa cells in a speckled pattern. Sillekens et al. (1988) reported that the predicted 159-amino acid SNRPC protein has an apparent molecular mass of 22 kD by SDS-PAGE.