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Immunoglobulin Associated Alpha (Iga)

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CD79a; MB-1; Membrane-bound immunoglobulin-associated protein; B-cell antigen receptor complex-associated protein alpha chain; MB-1 membrane glycoprotein

Immunoglobulin Associated Alpha (Iga)
CCC B381
HGNC 1698
MGI 101774
PubMed 16271957
RGD 1598036
UniProt P11912
Wiki CD79A

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.

The mouse mb1 gene was originally identified on the basis of its restricted expression in lymphocytes of B lineage. Predicted structural homology with the gamma chain of the CD3 complex of T cells led to the suggestion that the MB1 protein may associate with surface immunoglobulin on B cells and be involved in signal transduction.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB381Hu01 Recombinant Immunoglobulin Associated Alpha (Iga) Positive Control; Immunogen; SDS-PAGE; WB.
EPB381Hu61 Eukaryotic Immunoglobulin Associated Alpha (Iga) Positive Control; Immunogen; SDS-PAGE; WB.
APB381Hu61 Active Immunoglobulin Associated Alpha (Iga) Cell culture; Activity Assays.
Antibodies PAB381Hu01 Polyclonal Antibody to Immunoglobulin Associated Alpha (Iga) WB; IHC; FCM
Assay Kits n/a CLIA Kit for Immunoglobulin Associated Alpha (Iga) CLIA Kit Customized Service Offer
n/a ELISA Kit for Immunoglobulin Associated Alpha (Iga) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB381Mu01 Recombinant Immunoglobulin Associated Alpha (Iga) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB381Mu01 Polyclonal Antibody to Immunoglobulin Associated Alpha (Iga) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Immunoglobulin Associated Alpha (Iga) CLIA Kit Customized Service Offer
n/a ELISA Kit for Immunoglobulin Associated Alpha (Iga) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Immunoglobulin Associated Alpha (Iga) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Immunoglobulin Associated Alpha (Iga) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Immunoglobulin Associated Alpha (Iga) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Immunoglobulin Associated Alpha (Iga) CLIA Kit Customized Service Offer
n/a ELISA Kit for Immunoglobulin Associated Alpha (Iga) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB381Bo01 Recombinant Immunoglobulin Associated Alpha (Iga) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Immunoglobulin Associated Alpha (Iga) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Immunoglobulin Associated Alpha (Iga) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Immunoglobulin Associated Alpha (Iga) CLIA Kit Customized Service Offer
n/a ELISA Kit for Immunoglobulin Associated Alpha (Iga) ELISA Kit Customized Service Offer
  1. "Structure and expression of the mb-1 transcript in human lymphoid cells."Clin. Exp. Immunol. 90:141-146(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29."Eur. J. Immunol. 22:1621-1625(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning of the Ig-alpha subunit of the human B-cell antigen receptor complex."Immunogenetics 36:266-269(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Human mb-1 gene: complete cDNA sequence and its expression in B cells bearing membrane Ig of various isotypes."J. Immunol. 148:633-637(1992) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular cloning and expression pattern of a human gene homologous to the murine mb-1 gene."J. Immunol. 148:1526-1531(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Chromosomal localization, genomic structure, and allelic polymorphism of the human CD79 alpha (Ig-alpha/mb-1) gene."Immunogenetics 40:287-295(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Structure, chromosomal localization, and methylation pattern of the human mb-1 gene."J. Immunol. 152:5749-5757(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells."Mol. Immunol. 32:651-659(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex."Mol. Immunol. 31:419-427(1994) [PubMed] [Europe PMC] [Abstract]
  10. "B lymphocyte lineage-restricted expression of mb-1, a gene with CD3-like structural properties."EMBO J. 7:3457-3464(1988) [PubMed] [Europe PMC] [Abstract]
  11. "Cooperativity and segregation of function within the Ig-alpha/beta heterodimer of the B cell antigen receptor complex."J. Biol. Chem. 271:5158-5163(1996) [PubMed] [Europe PMC] [Abstract]
  12. "B-cell antigen receptor-induced apoptosis requires both Ig alpha and Ig beta."Blood 89:1513-1520(1997) [PubMed] [Europe PMC] [Abstract]
  13. "Mutations in Igalpha (CD79a) result in a complete block in B-cell development."J. Clin. Invest. 104:1115-1121(1999) [PubMed] [Europe PMC] [Abstract]
  14. "The serine and threonine residues in the Ig-alpha cytoplasmic tail negatively regulate immunoreceptor tyrosine-based activation motif-mediated signal transduction."Proc. Natl. Acad. Sci. U.S.A. 97:8451-8454(2000) [PubMed] [Europe PMC] [Abstract]
  15. "Novel Igalpha (CD79a) gene mutation in a Turkish patient with B cell-deficient agammaglobulinemia."Am. J. Med. Genet. 108:333-336(2002) [PubMed] [Europe PMC] [Abstract]
  16. "Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor."J. Biol. Chem. 275:16174-16182(2000) [PubMed] [Europe PMC] [Abstract]