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Anoctamin 1 (ANO1)

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TMEM16A; ORAOV2; DOG1; TAOS2; Oral Cancer Overexpressed 2; Tumor-amplified and overexpressed sequence 2; Discovered on gastrointestinal stromal tumors protein 1

Anoctamin 1 (ANO1)
CCC B384
HGNC 21625
MGI 2142149
PubMed 22314846
UniProt Q5XXA6
Wiki ANO1
TMEM16A, which encodes a deduced 986-amino acid protein. A shorter TMEM16A isoform results from alternative splicing. The human and mouse TMEM16A proteins share 89.9% sequence identity; both have 8 potential transmembrane regions with the N- and C-terminal tails facing the cytoplasm, 5 potential N-linked glycosylation sites, and a tyrosine phosphorylation site. TMEM16A shares 58.4%, 38.3%, and 38.6% amino acid sequence identity with C12ORF3 (TMEM16B), C11ORF25 (TMEM16C), and FLJ34272 (TMEM16D), respectively.In silico analysis indicated that TMEM16A mRNA is expressed in head and neck tumors, parathyroid tumors, and ovarian tumors, and in breast, pancreatic, gastric, and uterine cancers.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB384Hu01 Recombinant Anoctamin 1 (ANO1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Anoctamin 1 (ANO1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anoctamin 1 (ANO1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anoctamin 1 (ANO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anoctamin 1 (ANO1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB384Mu01 Recombinant Anoctamin 1 (ANO1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB384Mu01 Polyclonal Antibody to Anoctamin 1 (ANO1) WB; IHC; ICC; IP.
Assay Kits SEB384Mu ELISA Kit for Anoctamin 1 (ANO1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Comprehensive genome and transcriptome analysis of the 11q13 amplicon in human oral cancer and synteny to the 7F5 amplicon in murine oral carcinoma."Genes Chromosomes Cancer 45:1058-1069(2006) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products."Int. J. Oncol. 22:1375-1381(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status."Am. J. Pathol. 165:107-113(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Head and neck squamous cell carcinoma transcriptome analysis by comprehensive validated differential display."Oncogene 25:1821-1831(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Expression and function of epithelial anoctamins."J. Biol. Chem. 285:7838-7845(2010) [PubMed] [Europe PMC] [Abstract]
  8. "TMEM16A protein: a new identity for Ca(2+)-dependent Cl? channels."Physiology (Bethesda) 25:357-363(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?"Acta Pharmacol. Sin. 32:685-692(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "CFTR and TMEM16A are separate but functionally related Cl-channels."Cell. Physiol. Biochem. 28:715-724(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Characterization of the oligomeric structure of the Ca(2+)-activated Cl- channel Ano1/TMEM16A."J. Biol. Chem. 286:1381-1388(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Anoctamins."Pflugers Arch. 462:195-208(2011) [PubMed] [Europe PMC] [Abstract]
  14. "The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age."Exp. Physiol. 97:175-176(2012) [PubMed] [Europe PMC] [Abstract]
  15. "The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels."Exp. Physiol. 97:177-183(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Expression and function of epithelial anoctamins."Exp. Physiol. 97:184-192(2012) [PubMed] [Europe PMC] [Abstract]
  17. "Anoctamins are a family of Ca2+ activated Cl- channels."J. Cell Sci. 125:4991-4998(2012) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]