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Activating Transcription Factor 4 (ATF4)

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TAXREB67; TXREB; CREB-2; DNA-binding protein TAXREB67; Cyclic AMP-responsive element-binding protein 2; Tax-responsive enhancer element-binding protein 67

Activating Transcription Factor 4 (ATF4)
CCC B385
HGNC 786
MGI 88096
PubMed 23874395
RGD 621863
UniProt P18848
Wiki ATF4

Activating transcription factor 4 is  a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA-binding domain. Two alternative transcripts encoding the same protein have been described.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB385Hu01 Recombinant Activating Transcription Factor 4 (ATF4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB385Hu01 Polyclonal Antibody to Activating Transcription Factor 4 (ATF4) WB; IHC; ICC; IP.
MAB385Hu22 Monoclonal Antibody to Activating Transcription Factor 4 (ATF4) WB; IHC; ICC; IP.
Assay Kits SEB385Hu ELISA Kit for Activating Transcription Factor 4 (ATF4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB385Mu01 Recombinant Activating Transcription Factor 4 (ATF4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB385Mu01 Polyclonal Antibody to Activating Transcription Factor 4 (ATF4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Activating Transcription Factor 4 (ATF4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Activating Transcription Factor 4 (ATF4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB385Ra01 Recombinant Activating Transcription Factor 4 (ATF4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB385Ra01 Polyclonal Antibody to Activating Transcription Factor 4 (ATF4) WB; IHC; ICC; IP.
MAB385Ra21 Monoclonal Antibody to Activating Transcription Factor 4 (ATF4) WB; IHC; ICC; IP.
Assay Kits SEB385Ra ELISA Kit for Activating Transcription Factor 4 (ATF4) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I."J. Virol. 65:1420-1426(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element."Proc. Natl. Acad. Sci. U.S.A. 89:4820-4824(1992) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers."Genes Dev. 3:2083-2090(1989) [PubMed] [Europe PMC] [Abstract]
  6. ErratumGenes Dev. 4:682-682(1990)
  7. "TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death."EMBO J. 24:1243-1255(2005) [PubMed] [Europe PMC] [Abstract]
  8. "FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice."J. Cell Biol. 169:591-601(2005) [PubMed] [Europe PMC] [Abstract]
  9. "The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4." Nat. Genet. 38:674-681(2006) [PubMed] [Europe PMC] [Abstract]
  10. "C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene."J. Biol. Chem. 283:35106-35117(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome."J. Proteome Res. 9:6298-6316(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "New modularity of DAP-kinases: alternative splicing of the DRP-1 gene produces a ZIPk-like isoform."PLoS ONE 6:E17344-E17344(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA."J. Biol. Chem. 276:505-513(2001) [PubMed] [Europe PMC] [Abstract]