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Leukocyte Immunoglobulin Like Receptor Subfamily A, Member 2 (LILRA2)

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CD85h; LILR-A2; ILT1; LIR7; CD85 antigen-like family member H; Immunoglobulin-like transcript 1; Leukocyte immunoglobulin-like receptor 7

Leukocyte Immunoglobulin Like Receptor Subfamily A, Member 2 (LILRA2)
CCC B394
HGNC 6603
PubMed 18056355
UniProt Q8N149
Wiki LILRA2

Leukocyte immunoglobulin-like receptor subfamily A member 2 is a protein  encoded by the LILRA2 gene. Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells.

All LIRs in subfamily B have an inhibitory function . LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades. One member of subfamily A (LILRA3) lacks a transmembrane region and is presumed to be a soluble receptor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB394Hu01 Recombinant Leukocyte Immunoglobulin Like Receptor Subfamily A, Member 2 (LILRA2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB394Hu01 Polyclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily A, Member 2 (LILRA2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily A, Member 2 (LILRA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily A, Member 2 (LILRA2) ELISA Kit Customized Service Offer
  1. "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules."J. Immunol. 159:5192-5196(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes."Eur. J. Immunol. 39:3195-3206(2009) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Crystal structure of myeloid cell activating receptor leukocyte Ig-like receptor A2 (LILRA2/ILT1/LIR-7) domain swapped dimer: molecular basis for its non-binding to MHC complexes."J. Mol. Biol. 386:841-853(2009) [PubMed] [Europe PMC] [Abstract]