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Fc Fragment Of IgA Receptor (FcaR)

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CD89; FcaRI; Receptor I For The Fc Region Of Immunoglobulin A; IgA Fc receptor; Immunoglobulin alpha Fc receptor

Fc Fragment Of IgA Receptor (FcaR)
CCC B402
HGNC 3608
PubMed 22147912
UniProt P24071
Wiki FCAR

Only one Fc receptor belongs to the Fc alpha R subgroup, which is called Fc alpha RI (or CD89). Fc alpha RI is found on the surface of neutrophils, eosinophils, monocytes, some macrophages (including Kupffer cells), and some dendritic cells. It is composed of two extracellular Ig-like domains, and is a member of both the immunoglobulin superfamily and the multi-chain immune recognition receptor (MIRR) family. It signals by associating with two FcR gamma，signaling chains.

Another receptor can also bind IgA, although it has higher affinity for another antibody called IgM. This receptor is called the Fc-alpha/mu receptor (Fc alpha/mu R) and is a type I transmembrane protein. With one Ig-like domain in its extracellular portion, this Fc receptor is also a member of the immunoglobulin superfamily.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB402Hu01 Recombinant Fc Fragment Of IgA Receptor (FcaR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB402Hu01 Polyclonal Antibody to Fc Fragment Of IgA Receptor (FcaR) WB; IHC; ICC; IP.
MAB402Hu22 Monoclonal Antibody to Fc Fragment Of IgA Receptor (FcaR) WB; IHC; ICC; IP.
Assay Kits SEB402Hu ELISA Kit for Fc Fragment Of IgA Receptor (FcaR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB402Ra01 Recombinant Fc Fragment Of IgA Receptor (FcaR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB402Ra01 Polyclonal Antibody to Fc Fragment Of IgA Receptor (FcaR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Fc Fragment Of IgA Receptor (FcaR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fc Fragment Of IgA Receptor (FcaR) ELISA Kit Customized Service Offer
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  2. "Structure of the gene for the human myeloid IgA Fc receptor (CD89)."J. Immunol. 155:1203-1209(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of Fc alpha receptor (CD89) isoforms generated by alternative splicing that are differentially expressed between blood monocytes and alveolar macrophages."J. Immunol. 156:4442-4448(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Alternative splicing of the human IgA Fc receptor CD89 in neutrophils and eosinophils."Biochem. J. 318:771-777(1996) [PubMed] [Europe PMC] [Abstract]
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  10. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
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  12. "Insights into IgA-mediated immune responses from the crystal structures of human FcalphaRI and its complex with IgA1-Fc."Nature 423:614-620(2003) [PubMed] [Europe PMC] [Abstract]