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Killer Cell Lectin Like Receptor Subfamily D, Member 1 (KLRD1)

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CD94; KLR-D1; Natural killer cells antigen CD94; NK cell receptor

Killer Cell Lectin Like Receptor Subfamily D, Member 1 (KLRD1)
CCC B407
HGNC 6378
MGI 1196275
PubMed 18083576
RGD 2978
UniProt Q13241
Wiki KLRD1

KLRD1 is a lectin, cluster of differentiation and a receptor that is involved in cell signaling and is expressed on the surface of natural killer cells in the innate immune system. CD94 pairs with the NKG2 molecule as a heterodimer. The CD94/NKG2 complex, on the surface of natural killer cells interacts with Human Leukocyte Antigen (HLA)-E on target cells.

Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB407Hu01 Recombinant Killer Cell Lectin Like Receptor Subfamily D, Member 1 (KLRD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB407Hu01 Polyclonal Antibody to Killer Cell Lectin Like Receptor Subfamily D, Member 1 (KLRD1) WB; IHC; ICC; IP.
MAB407Hu21 Monoclonal Antibody to Killer Cell Lectin Like Receptor Subfamily D, Member 1 (KLRD1) WB; IHC; ICC; IP.
Assay Kits SEB407Hu ELISA Kit for Killer Cell Lectin Like Receptor Subfamily D, Member 1 (KLRD1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Killer Cell Lectin Like Receptor Subfamily D, Member 1 (KLRD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Killer Cell Lectin Like Receptor Subfamily D, Member 1 (KLRD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Killer Cell Lectin Like Receptor Subfamily D, Member 1 (KLRD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Killer Cell Lectin Like Receptor Subfamily D, Member 1 (KLRD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Killer Cell Lectin Like Receptor Subfamily D, Member 1 (KLRD1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Killer Cell Lectin Like Receptor Subfamily D, Member 1 (KLRD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Killer Cell Lectin Like Receptor Subfamily D, Member 1 (KLRD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Killer Cell Lectin Like Receptor Subfamily D, Member 1 (KLRD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Killer Cell Lectin Like Receptor Subfamily D, Member 1 (KLRD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Killer Cell Lectin Like Receptor Subfamily D, Member 1 (KLRD1) ELISA Kit Customized Service Offer
  1. "Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily."Eur. J. Immunol. 25:2433-2437(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Structure of the human CD94 C-type lectin gene."Immunogenetics 47:305-309(1998) [PubMed] [Europe PMC] [Abstract]
  3. "A alternatively spliced form of the human CD94 gene."Immunogenetics 48:87-88(1998) [PubMed] [Europe PMC] [Abstract]
  4. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94/NKG2 receptors."Immunity 10:75-82(1999) [PubMed] [Europe PMC] [Abstract]
  7. "The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition."Immunity 27:900-911(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Structural basis for NKG2A/CD94 recognition of HLA-E."Proc. Natl. Acad. Sci. U.S.A. 105:6696-6701(2008) [PubMed] [Europe PMC] [Abstract]
  9. "CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence."J. Exp. Med. 205:725-735(2008) [PubMed] [Europe PMC] [Abstract]