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Cluster Of Differentiation 97 (CD97)

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TM7LN1; TM7-LN1; Seven-Span Transmembrane Protein; Seven-Transmembrane,Heterodimeric Receptor Associated With Inflammation; Seven Transmembrane Helix Receptor

Cluster Of Differentiation 97 (CD97)
CCC B410
HGNC 1711
MGI 1347095
PubMed 12417446
RGD 1305595
UniProt P48960
Wiki CD97

CD97 antigen is a glycoprotein that is present on the surface of most activated leukocytes and spans the membrane seven times, which is a defining feature of G protein-coupled receptors. The protein has an extended extracellular region with several N-terminal epidermal growth factor (EGF)-like domains, which mediate binding to its cellular ligand, decay accelerating factor (DAF, CD55), a regulatory protein of the complement cascade.

The presence of structural features characteristic of extracellular matrix proteins and transmembrane proteins suggests that this protein is a receptor involved in both cell adhesion and signaling processes early after leukocyte activation. Alternative splicing has been observed for this gene and three variants have been found.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB410Hu01 Recombinant Cluster Of Differentiation 97 (CD97) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAB410Hu21 Monoclonal Antibody to Cluster Of Differentiation 97 (CD97) WB; IHC; ICC; IP.
MAB410Hu22 Monoclonal Antibody to Cluster Of Differentiation 97 (CD97) WB; IHC; ICC; IP.
MAB410Hu23 Monoclonal Antibody to Cluster Of Differentiation 97 (CD97) WB; IHC; ICC; IP.
MAB410Hu24 Monoclonal Antibody to Cluster Of Differentiation 97 (CD97) WB; IHC; ICC; IP.
PAB410Hu01 Polyclonal Antibody to Cluster Of Differentiation 97 (CD97) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 97 (CD97) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 97 (CD97) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB410Mu01 Recombinant Cluster Of Differentiation 97 (CD97) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB410Mu01 Polyclonal Antibody to Cluster Of Differentiation 97 (CD97) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 97 (CD97) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 97 (CD97) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB410Ra01 Recombinant Cluster Of Differentiation 97 (CD97) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB410Ra01 Polyclonal Antibody to Cluster Of Differentiation 97 (CD97) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 97 (CD97) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 97 (CD97) ELISA Kit Customized Service Offer
  1. "Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of the secretion receptor superfamily with an unusual extracellular domain."J. Immunol. 155:1942-1950(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Structure of the human CD97 gene: exon shuffling has generated a new type of seven-span transmembrane molecule related to the secretin receptor superfamily."Genomics 32:144-147(1996) [PubMed] [Europe PMC] [Abstract]
  3. "CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation."J. Immunol. 157:5438-5447(1996) [PubMed] [Europe PMC] [Abstract]
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  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]