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Mitogen Activated Protein Kinase 11 (MAPK11)

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P38B; P38Beta2; PRKM11; SAPK2; SAPK2B; P38-2; P38Beta; Mitogen-activated protein kinase p38 beta; Stress-activated protein kinase 2b

Mitogen Activated Protein Kinase 11 (MAPK11)
CCC B435
HGNC 6873
MGI 1338024
PubMed 16287858
UniProt Q15759
Wiki MAPK11

Mitogen-activated protein kinase 11 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase. EGF-stimulated cytotrophoblast differentiation to syncytium requires MAPK11/14 activation, and that cytotrophoblast proliferation can be stimulated in culture by EGF and enhanced by MAPK11/14 inhibition with a consequent reduction of differentiation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB435Hu01 Recombinant Mitogen Activated Protein Kinase 11 (MAPK11) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB435Hu01 Polyclonal Antibody to Mitogen Activated Protein Kinase 11 (MAPK11) WB; ICC; IHC-P; IHC-F; ELISA.
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase 11 (MAPK11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase 11 (MAPK11) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase 11 (MAPK11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase 11 (MAPK11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase 11 (MAPK11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase 11 (MAPK11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase 11 (MAPK11) ELISA Kit Customized Service Offer
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  3. "Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6."J. Biol. Chem. 273:1741-1748(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases."EMBO J. 16:3563-3571(1997) [PubMed] [Europe PMC] [Abstract]
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  14. "Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression."J. Immunol. 173:3979-3990(2004) [PubMed] [Europe PMC] [Abstract]
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