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Cluster Of Differentiation 109 (CD109)

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CPAMD7; p180; r150; Gov platelet alloantigens; 150 kDa TGF-beta-1-binding protein; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7

Cluster Of Differentiation 109 (CD109)
CCC B458
HGNC 21685
MGI 2445221
PubMed 18429827
RGD 1311287
UniProt Q6YHK3
Wiki CD109

CD109 is a GPI-linked cell surface antigen expressed by CD34 acute myeloid leukemia cell lines, T-cell lines, activated T lymphoblasts, endothelial cells, and activated platelets (Lin et al., 2002). In addition, the platelet-specific Gov antigen system, implicated in refractoriness to platelet transfusion, neonatal alloimmune thrombocytopenia, and posttransfusion purpura, is carried by CD109 (Kelton et al., 1990; Lin et al., 2002).

CD109 encodes a deduced 1,445-amino acid protein with a predicted molecular mass of approximately 162 kD. The protein contains a cleavable 21 residue N-terminal sequence, 17 potential N-linked glycosylation sites, a GPI anchor site, and a thioester motif characteristic of the alpha-2-macroglobulin (A2M)/complement (AMCOM) family.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB458Hu01 Recombinant Cluster Of Differentiation 109 (CD109) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB458Hu01 Polyclonal Antibody to Cluster Of Differentiation 109 (CD109) WB; IHC; ICC; IP.
MAB458Hu21 Monoclonal Antibody to Cluster Of Differentiation 109 (CD109) WB; IHC; ICC; IP.
Assay Kits SEB458Hu ELISA Kit for Cluster Of Differentiation 109 (CD109) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB458Mu01 Recombinant Cluster Of Differentiation 109 (CD109) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB458Mu01 Polyclonal Antibody to Cluster Of Differentiation 109 (CD109) WB; IHC; ICC; IP.
Assay Kits SEB458Mu ELISA Kit for Cluster Of Differentiation 109 (CD109) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB458Ra01 Recombinant Cluster Of Differentiation 109 (CD109) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB458Ra01 Polyclonal Antibody to Cluster Of Differentiation 109 (CD109) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 109 (CD109) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 109 (CD109) ELISA Kit Customized Service Offer
  1. "Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins."Blood 99:1683-1691(2002) [PubMed] [Europe PMC] [Abstract]
  2. "CD109 represents a novel branch of the alpha2-macroglobulin/complement gene family."Gene 327:171-183(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes."FASEB J. 20:1525-1527(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  7. "A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens."Blood 99:1692-1698(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of a cell-surface antigen associated with activated T lymphoblasts and activated platelets."Blood 77:84-93(1991) [PubMed] [Europe PMC] [Abstract]
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]