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Poliovirus Receptor Related Protein 1 (PVRL1)

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CD111; HVEC; PRR1; CLPED1; ED4; HIgR; OFC7; PRR; PVRR1; SK12; Nectin 1; Herpesvirus Entry Mediator C; Herpesvirus Ig-like receptor

Poliovirus Receptor Related Protein 1 (PVRL1)
CCC B470
HGNC 9706
MGI 1926483
PubMed 11559849
RGD 620791
UniProt Q15223
Wiki PVRL1

  • PVRL1, or nectin-1, belongs to the nectin subfamily of immunoglobulin-like adhesion molecules that participate in Ca(2+)-independent cell-cell adhesion. Nectins bind to the actin cytoskeleton through the adaptor protein afadin (MLLT4) and are key components of adherens junctions (summary by Barron et al. (2008)).

  • Members of the immunoglobin (Ig) superfamily have been shown to serve as receptors for various viruses. The human poliovirus receptor (PVR) is an integral membrane protein with one V-like extracellular Ig domain, 2 C-like extracellular Ig domains, a transmembrane region, and an intracytoplasmic region. Lopez et al. (1995) isolated a cDNA for a poliovirus receptor related gene, which they symbolized PRR.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB470Hu01 Recombinant Poliovirus Receptor Related Protein 1 (PVRL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB470Hu01 Polyclonal Antibody to Poliovirus Receptor Related Protein 1 (PVRL1) WB; IHC; ICC; IP.
MAB470Hu21 Monoclonal Antibody to Poliovirus Receptor Related Protein 1 (PVRL1) WB; IHC; ICC; IP.
Assay Kits SEB470Hu ELISA Kit for Poliovirus Receptor Related Protein 1 (PVRL1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Poliovirus Receptor Related Protein 1 (PVRL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Poliovirus Receptor Related Protein 1 (PVRL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Poliovirus Receptor Related Protein 1 (PVRL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Poliovirus Receptor Related Protein 1 (PVRL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Poliovirus Receptor Related Protein 1 (PVRL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Poliovirus Receptor Related Protein 1 (PVRL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Poliovirus Receptor Related Protein 1 (PVRL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Poliovirus Receptor Related Protein 1 (PVRL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Poliovirus Receptor Related Protein 1 (PVRL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Poliovirus Receptor Related Protein 1 (PVRL1) ELISA Kit Customized Service Offer
  1. "cDNA characterization and chromosomal localization of a gene related to the poliovirus receptor gene."Gene 155:261-265(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor."Science 280:1618-1620(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Novel, soluble isoform of the herpes simplex virus (HSV) receptor nectin1 (or prr1-HIgR-Hvec) modulates positively and negatively susceptibility to hsv infection."J. Virol. 75:5684-5691(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Mutations of PVRL1, encoding a cell-cell adhesion molecule/herpesvirus receptor, in cleft lip/palate-ectodermal dysplasia."Nat. Genet. 25:427-430(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Herpes simplex virus glycoprotein D can bind to poliovirus receptor-related protein 1 or herpesvirus entry mediator, two structurally unrelated mediators of virus entry."J. Virol. 72:7064-7074(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein."J. Cell Biol. 145:539-549(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction."J. Biol. Chem. 276:43205-43215(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Interaction of integrin alpha(v)beta3 with nectin. Implication in cross-talk between cell-matrix and cell-cell junctions."J. Biol. Chem. 281:19631-19644(2006) [PubMed] [Europe PMC] [Abstract]
  11. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion."Nat. Commun. 2:577-577(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1."PLoS Pathog. 7:E1002277-E1002277(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Nectin ectodomain structures reveal a canonical adhesive interface."Nat. Struct. Mol. Biol. 19:906-915(2012) [PubMed] [Europe PMC] [Abstract]