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Nectin 2 (NECTIN2)

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CD112; PVRL2; HVEB; PRR2; PVRR2; Herpesvirus Entry Mediator B; Herpes virus entry mediator B

Nectin 2 (NECTIN2)
CCC B474
HGNC 9707
MGI 97822
PubMed 17696193
RGD 1309505
UniProt Q92692
Wiki PVRL2

Poliovirus receptor-related 2 is a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions.

It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.Expression of PVR or PVRL2 rendered cells susceptible to enhanced lysis in a DNAM1-dependent manner that was nearly abrogated in the presence of antibody to PVR, PVRL2, or DNAM1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB474Hu01 Recombinant Nectin 2 (NECTIN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB474Hu01 Polyclonal Antibody to Nectin 2 (NECTIN2) WB; IHC; ICC; IP.
LAB474Hu71 Biotin-Linked Polyclonal Antibody to Nectin 2 (NECTIN2) WB; IHC; ICC.
MAB474Hu21 Monoclonal Antibody to Nectin 2 (NECTIN2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Nectin 2 (NECTIN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nectin 2 (NECTIN2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB474Mu01 Recombinant Nectin 2 (NECTIN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB474Mu01 Polyclonal Antibody to Nectin 2 (NECTIN2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Nectin 2 (NECTIN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nectin 2 (NECTIN2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nectin 2 (NECTIN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nectin 2 (NECTIN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nectin 2 (NECTIN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nectin 2 (NECTIN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nectin 2 (NECTIN2) ELISA Kit Customized Service Offer
  1. "The human PRR2 gene, related to the human poliovirus receptor gene (PVR), is the true homolog of the murine MPH gene."Gene 159:267-272(1995) [PubMed] [Europe PMC] [Abstract]
  2. "A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus."Virology 246:179-189(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1."DNA Seq. 9:89-100(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Structural features of nectin-2 (HveB) required for herpes simplex virus entry."J. Virol. 75:11185-11195(2001) [PubMed] [Europe PMC] [Abstract]
  7. "PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis."Mol. Immunol. 42:463-469(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells."Nat. Immunol. 10:48-57(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion."Proc. Natl. Acad. Sci. U.S.A. 109:14836-14840(2012) [PubMed] [Europe PMC] [Abstract]