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Mannose Binding Lectin (MBL)

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MBL2; COLEC1; HSMBPC; MBP1; MBP; Collectin-1; Mannose-binding protein C; Mannan Binding Protein; Mannose-Binding Lectin(Protein C)2,Soluble(Opsonic Defect)

Mannose Binding Lectin (MBL)
CCC B480
HGNC 6922
MGI 96924
PubMed 19594626
RGD 67380
UniProt P11226
Wiki MBL

Mannosebinding protein (MBP), initiates the lectin branch of the innate immune response by binding to the surface of potentially pathogenic microorganisms and initiating complement fixation through an N-terminal collagen-like domain. MBL is a key component in immune response in that it can directly trigger neutralization of invading microorganisms by an Ab-independent mechanism.

It binds to sugars on the surface of bacterial, fungal and parasitic cells through C-terminal, Ca2 -dependent carbohydrate-recognition domains. Mutations of human MBL are associated with immunodeficiency resulting from a reduction in the ability of the mutant MBL to initiate complement fixation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB480Hu01 Recombinant Mannose Binding Lectin (MBL) Positive Control; Immunogen; SDS-PAGE; WB.
RPB480Hu02 Recombinant Mannose Binding Lectin (MBL) Positive Control; Immunogen; SDS-PAGE; WB.
RPB480Hu03 Recombinant Mannose Binding Lectin (MBL) Positive Control; Immunogen; SDS-PAGE; WB.
APB480Hu02 Active Mannose Binding Lectin (MBL) Cell culture; Activity Assays.
EPB480Hu61 Eukaryotic Mannose Binding Lectin (MBL) Positive Control; Immunogen; SDS-PAGE; WB.
APB480Hu61 Active Mannose Binding Lectin (MBL) Cell culture; Activity Assays.
Antibodies PAB480Hu01 Polyclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IP.
MAB480Hu22 Monoclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IP.
PAB480Hu02 Polyclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IP.
LAB480Hu71 Biotin-Linked Polyclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC.
PAB480Hu03 Polyclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IP.
Assay Kits SEB480Hu ELISA Kit for Mannose Binding Lectin (MBL) Enzyme-linked immunosorbent assay for Antigen Detection.
AEB480Hu ELISA Kit for Anti-Mannose Binding Lectin Antibody (Anti-MBL) Enzyme-linked immunosorbent assay for Antibody Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB480Mu01 Recombinant Mannose Binding Lectin (MBL) Positive Control; Immunogen; SDS-PAGE; WB.
RPB480Mu02 Recombinant Mannose Binding Lectin (MBL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB480Mu01 Polyclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IP.
PAB480Mu02 Polyclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IP.
Assay Kits SEB480Mu ELISA Kit for Mannose Binding Lectin (MBL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB480Ra01 Recombinant Mannose Binding Lectin (MBL) Positive Control; Immunogen; SDS-PAGE; WB.
RPB480Ra02 Recombinant Mannose Binding Lectin (MBL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB480Ra01 Polyclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IP.
LAB480Ra71 Biotin-Linked Polyclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC.
PAB480Ra02 Polyclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IP.
Assay Kits SEB480Ra ELISA Kit for Mannose Binding Lectin (MBL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB480Ga01 Recombinant Mannose Binding Lectin (MBL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB480Ga01 Polyclonal Antibody to Mannose Binding Lectin (MBL) WB
MAB480Ga21 Monoclonal Antibody to Mannose Binding Lectin (MBL) WB; IHC; ICC; IP.
Assay Kits SEB480Ga ELISA Kit for Mannose Binding Lectin (MBL) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "A human mannose-binding protein is an acute-phase reactant that shares sequence homology with other vertebrate lectins."J. Exp. Med. 167:1034-1046(1988) [PubMed] [Europe PMC] [Abstract]
  2. ErratumJ. Exp. Med. 174:753-753(1991)
  3. "The human mannose-binding protein gene. Exon structure reveals its evolutionary relationship to a human pulmonary surfactant gene and localization to chromosome 10."J. Exp. Med. 170:1175-1189(1989) [PubMed] [Europe PMC] [Abstract]
  4. "Structure and evolutionary origin of the gene encoding a human serum mannose-binding protein."Biochem. J. 262:763-771(1989) [PubMed] [Europe PMC] [Abstract]
  5. "Different molecular events result in low protein levels of mannan-binding lectin in populations from South-East Africa and South America."J. Immunol. 161:3169-3175(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Cloning and sequencing of mannan-binding lectin cDNA of Chinese."Mian Yi Xue Za Zhi 15:83-86(1999)
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Restricted polymorphisms of the mannose-binding lectin gene in a population of Papua New Guinea."Mutat. Res. 505:87-91(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Structure and function of mannan-binding proteins isolated from human liver and serum."J. Biochem. 115:1148-1154(1994) [PubMed] [Europe PMC] [Abstract]
  10. "A second serine protease associated with mannan-binding lectin that activates complement."Nature 386:506-510(1997) [PubMed] [Europe PMC] [Abstract]
  11. "Mannose-binding lectin engagement with late apoptotic and necrotic cells."Eur. J. Immunol. 33:2853-2863(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Nucleic acid is a novel ligand for innate, immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin."J. Biol. Chem. 279:32728-32736(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Mannan-binding protein blocks the activation of metalloproteases meprin alpha and beta."J. Immunol. 175:3177-3185(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Comparative study of the human ficolins reveals unique features of Ficolin-3 (Hakata antigen)."Mol. Immunol. 45:1623-1632(2008) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Human mannose-binding protein carbohydrate recognition domain trimerizes through a triple alpha-helical coiled-coil."Nat. Struct. Biol. 1:789-794(1994) [PubMed] [Europe PMC] [Abstract]
  17. "Molecular basis of opsonic defect in immunodeficient children."Lancet 337:1569-1570(1991) [PubMed] [Europe PMC] [Abstract]
  18. "High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene."Hum. Mol. Genet. 1:709-715(1992) [PubMed] [Europe PMC] [Abstract]
  19. ErratumHum. Mol. Genet. 2:342-342(1993)
  20. "Distinct and overlapping functions of allelic forms of human mannose binding protein."Nat. Genet. 2:50-55(1992) [PubMed] [Europe PMC] [Abstract]
  21. "Genotyping of the three major allelic variants of the human mannose-binding lectin gene by denaturing gradient gel electrophoresis."Hum. Mutat. 14:80-83(1999) [PubMed] [Europe PMC] [Abstract]
  22. "Mannose binding lectin genotypes influence recovery from hepatitis B virus infection."J. Virol. 79:9192-9196(2005) [PubMed] [Europe PMC] [Abstract]
  23. "Variant G57E of mannose binding lectin associated with protection against tuberculosis caused by Mycobacterium africanum but not by M. tuberculosis."PLoS ONE 6:E20908-E20908(2011) [PubMed] [Europe PMC] [Abstract]