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Mucin 6 (MUC6)

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Mucin 6,Gastric; Oligomeric Mucus/Gel-Forming

Mucin 6 (MUC6)
CCC B489
HGNC 7517
MGI 2663233
PubMed 18410610
UniProt Q6W4X9
Wiki MUC6

Reid and Harris (1998) used tissue in situ hybridization to study MUC6 gene expression in midtrimester human fetal gut. MUC6 mRNA was detected at low levels in the small intestine between 13 and 23 weeks' gestation. Abundant MUC6 mRNA was detected in gastric neck mucous cells, in contrast with MUC5AC . MUC6 mRNA was present at high levels in pancreatic ductal epithelium throughout the midtrimester.

Rousseau et al. (2004) described the domain structure of human MUC6. MUC6 contains an N-terminal signal peptide, followed by several Von Willebrand factor (VWF)-like domains, a large tandem repeat domain, and a C-terminal cystine knot domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB489Hu01 Recombinant Mucin 6 (MUC6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB489Hu01 Polyclonal Antibody to Mucin 6 (MUC6) WB; IHC; ICC; IP.
MAB489Hu22 Monoclonal Antibody to Mucin 6 (MUC6) WB; IHC; ICC; IP.
LAB489Hu71 Biotin-Linked Polyclonal Antibody to Mucin 6 (MUC6) WB; IHC; ICC.
Assay Kits SEB489Hu ELISA Kit for Mucin 6 (MUC6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mucin 6 (MUC6) Recombinant Protein Customized Service Offer
Antibodies PAB489Mu01 Polyclonal Antibody to Mucin 6 (MUC6) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Mucin 6 (MUC6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mucin 6 (MUC6) ELISA Kit Customized Service Offer
  1. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The complete genomic organization of the human MUC6 and MUC2 mucin genes."Genomics 83:936-939(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human gastric mucin. Identification of a unique species by expression cloning."J. Biol. Chem. 268:5879-5885(1993) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The carboxyl-terminal sequence of the human secretory mucin, MUC6. Analysis of the primary amino acid sequence."J. Biol. Chem. 272:16398-16403(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Human mucin genes MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism. An improved method to analyze large mRNAs."J. Biol. Chem. 273:881-890(1998) [PubMed] [Europe PMC] [Abstract]
  7. "The MUC6 secretory mucin gene is expressed in a wide variety of epithelial tissues."J. Pathol. 186:398-405(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Expression of the MUC 6 mucin gene in development of the human kidney and male genital ducts."J. Histochem. Cytochem. 47:817-822(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution."Biochem. J. 364:191-200(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Aberrant epithelial expression of trefoil family factor 2 and mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisation."J. Clin. Pathol. 57:861-866(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Upregulation of MUC6 mucin gene expression by NFkappaB and Sp factors."Biochem. Biophys. Res. Commun. 333:1254-1260(2005) [PubMed] [Europe PMC] [Abstract]