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Interferon Gamma Receptor 1 (IFNgR1)

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CD119

Interferon Gamma Receptor 1 (IFNgR1)
CCC B491
HGNC 5439
MGI 107655
PubMed 10192386
RGD 620570
UniProt P15260
Wiki CD119

Interferons may be regarded as polypeptide hormones because of their role in communicating from cell to cell a specific set of instructions that lead to a wide variety of effects. Viruses induce type I interferon, subdivided into alpha-interferon, produced by leukocytes or lymphoblastoid cells, and beta-interferon , produced by fibroblasts. Mitogens and antigenic stimuli induce in lymphocytes type II, immune, or gamma-interferon .

The biologic effects of human interferons, including increment of histocompatibility antigens, are mediated through species-specific receptors. Human interferons are not active, for example, in mouse cells. The human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. IFNGR1 is the ligand-binding subunit.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB491Hu01 Recombinant Interferon Gamma Receptor 1 (IFNgR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB491Hu01 Polyclonal Antibody to Interferon Gamma Receptor 1 (IFNgR1) WB; ICC; IHC-P; IHC-F; ELISA.
MAB491Hu21 Monoclonal Antibody to Interferon Gamma Receptor 1 (IFNgR1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Interferon Gamma Receptor 1 (IFNgR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Gamma Receptor 1 (IFNgR1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB491Mu01 Recombinant Interferon Gamma Receptor 1 (IFNgR1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB491Mu02 Recombinant Interferon Gamma Receptor 1 (IFNgR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB491Mu01 Polyclonal Antibody to Interferon Gamma Receptor 1 (IFNgR1) WB; IHC; ICC; IP.
LAB491Mu71 Biotin-Linked Polyclonal Antibody to Interferon Gamma Receptor 1 (IFNgR1) WB; IHC; ICC.
LAB491Mu81 FITC-Linked Polyclonal Antibody to Interferon Gamma Receptor 1 (IFNgR1) WB; IHC; ICC; IF.
PAB491Mu02 Polyclonal Antibody to Interferon Gamma Receptor 1 (IFNgR1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Interferon Gamma Receptor 1 (IFNgR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Gamma Receptor 1 (IFNgR1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interferon Gamma Receptor 1 (IFNgR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interferon Gamma Receptor 1 (IFNgR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Gamma Receptor 1 (IFNgR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Gamma Receptor 1 (IFNgR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Gamma Receptor 1 (IFNgR1) ELISA Kit Customized Service Offer
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  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Alignment of disulfide bonds of the extracellular domain of the interferon gamma receptor and investigation of their role in biological activity."Biochemistry 32:2423-2430(1993) [PubMed] [Europe PMC] [Abstract]
  6. "A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection." Nat. Genet. 21:370-378(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor."Nature 376:230-235(1995) [PubMed] [Europe PMC] [Abstract]
  8. "Neutralizing epitopes on the extracellular interferon gamma receptor (IFNgammaR) alpha-chain characterized by homolog scanning mutagenesis and X-ray crystal structure of the A6 fab-IFNgammaR1-108 complex."J. Mol. Biol. 273:882-897(1997) [PubMed] [Europe PMC] [Abstract]
  9. "Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex."Structure 8:927-936(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Partial interferon-gamma receptor 1 deficiency in a child with tuberculoid bacillus Calmette-Guerin infection and a sibling with clinical tuberculosis."J. Clin. Invest. 100:2658-2664(1997) [PubMed] [Europe PMC] [Abstract]
  11. "In a novel form of IFN-gamma receptor 1 deficiency, cell surface receptors fail to bind IFN-gamma."J. Clin. Invest. 105:1429-1436(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Genomewide linkage analysis identifies polymorphism in the human interferon-gamma receptor affecting Helicobacter pylori infection."Am. J. Hum. Genet. 72:448-453(2003) [PubMed] [Europe PMC] [Abstract]