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Chemokine C-X3-C-Motif Receptor 1 (CX3CR1)

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CCRL1; CMKBRL1; CMKDR1; GPR13; GPRV28; V28; Beta chemokine receptor-like 1; Fractalkine receptor; G-protein coupled receptor 13

Chemokine C-X3-C-Motif Receptor 1 (CX3CR1)
CCC B523
HGNC 2558
MGI 1333815
PubMed 15653504
RGD 620137
UniProt P49238
Wiki CX3CR1
Only one member belongs to the CX3C sub-family of chemokine receptors - CR1. As the name suggests, this receptor binds the chemokine CX3CL1 (also called neurotactin or fractalkine).Raport et al. (1995) used human-mouse somatic cell hybrids to map the V28 (CX3CR1) gene to 3pter-p21, near CMKBR1. Based on the sequence similarity of V28 to several chemokine receptors, its expression in leukocytes, and its chromosomal location near CMKBR1, Raport et al. (1995) speculated that V28 may be a member of the chemokine receptor (CCR) family. By radiation hybrid analysis and organization of BAC contigs by FISH on combed genomic DNA, Maho et al. (1999) localized the CX3CR1 gene within the CCR cluster at 3p21.3.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB523Hu01 Recombinant Chemokine C-X3-C-Motif Receptor 1 (CX3CR1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB523Hu02 Recombinant Chemokine C-X3-C-Motif Receptor 1 (CX3CR1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB523Hu03 Recombinant Chemokine C-X3-C-Motif Receptor 1 (CX3CR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB523Hu01 Polyclonal Antibody to Chemokine C-X3-C-Motif Receptor 1 (CX3CR1) WB; IHC; ICC; IP.
MAB523Hu21 Monoclonal Antibody to Chemokine C-X3-C-Motif Receptor 1 (CX3CR1) WB; IHC; ICC; IP.
PAB523Hu02 Polyclonal Antibody to Chemokine C-X3-C-Motif Receptor 1 (CX3CR1) WB; IHC; ICC; IP.
Assay Kits SEB523Hu ELISA Kit for Chemokine C-X3-C-Motif Receptor 1 (CX3CR1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB523Mu01 Recombinant Chemokine C-X3-C-Motif Receptor 1 (CX3CR1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB523Mu02 Recombinant Chemokine C-X3-C-Motif Receptor 1 (CX3CR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB523Mu01 Polyclonal Antibody to Chemokine C-X3-C-Motif Receptor 1 (CX3CR1) WB; IHC; ICC; IP.
PAB523Mu02 Polyclonal Antibody to Chemokine C-X3-C-Motif Receptor 1 (CX3CR1) WB; IHC; ICC; IP.
Assay Kits SEB523Mu ELISA Kit for Chemokine C-X3-C-Motif Receptor 1 (CX3CR1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chemokine C-X3-C-Motif Receptor 1 (CX3CR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chemokine C-X3-C-Motif Receptor 1 (CX3CR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chemokine C-X3-C-Motif Receptor 1 (CX3CR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chemokine C-X3-C-Motif Receptor 1 (CX3CR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chemokine C-X3-C-Motif Receptor 1 (CX3CR1) ELISA Kit Customized Service Offer
  1. "The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues."Gene 163:295-299(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning, chromosomal localization, and RNA expression of a human beta chemokine receptor-like gene."DNA Cell Biol. 14:673-680(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic organization and evolution of the CX3CR1/CCR8 chemokine receptor locus."J. Biol. Chem. 278:11985-11994(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein."Nat. Immunol. 2:732-738(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Two novel fully functional isoforms of CX3CR1 are potent HIV coreceptors."J. Immunol. 171:5305-5312(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion."Cell 91:521-530(1997) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1."J. Biol. Chem. 273:23799-23804(1998) [PubMed] [Europe PMC] [Abstract]
  11. "Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1."Science 287:2274-2277(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease."Blood 97:1925-1928(2001) [PubMed] [Europe PMC] [Abstract]
  13. "The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration."FASEB J. 18:1297-1299(2004) [PubMed] [Europe PMC] [Abstract]
  14. "CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration."J. Clin. Invest. 117:2920-2928(2007) [PubMed] [Europe PMC] [Abstract]