Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9)
[Edit]CD137; CDw137; 4-1BB; ILA; Induced By Lymphocyte Activation; T-cell antigen 4-1BB homolog
CD137 is a member of the tumor necrosis factor (TNF) receptor family. CD137 is a member of the tumor necrosis factor (TNF) receptor family. Its alternative names are tumor necrosis factor receptor superfamily member 9 (TNFRSF9), 4-1BB and induced by lymphocyte activation (ILA).CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation.The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPB527Hu01 | Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) | Positive Control; Immunogen; SDS-PAGE; WB. |
APB527Hu01 | Active Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) | Cell culture; Activity Assays. | |
Antibodies | PAB527Hu01 | Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) | WB;FCM |
LAB527Hu71 | Biotin-Linked Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) | WB; IHC; ICC. | |
Assay Kits | SEB527Hu | ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPB527Mu01 | Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | n/a | Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) | ELISA Kit Customized Service Offer |
- "Molecular and biological characterization of human 4-1BB and its ligand."Eur. J. Immunol. 24:2219-2227(1994) [PubMed] [Europe PMC] [Abstract]
- "A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family."Gene 134:295-298(1993) [PubMed] [Europe PMC] [Abstract]
- "Characterization of human homologue of 4-1BB and its ligand."Immunol. Lett. 45:67-73(1995) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
- "4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB."Mol. Cell. Biol. 18:558-565(1998) [PubMed] [Europe PMC] [Abstract]
- "CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand."J. Exp. Med. 187:1849-1862(1998) [PubMed] [Europe PMC] [Abstract]
- "A novel leucine-rich repeat protein (LRR-1): potential involvement in 4-1BB-mediated signal transduction."Mol. Cells 12:304-312(2001) [PubMed] [Europe PMC] [Abstract]
- "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]