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Cyclophilin 40 (CYP-40)

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PPID; CYPD; CyP-D; PPIase D; Peptidylprolyl Isomerase D; Cyclophilin 40; 40 kDa peptidyl-prolyl cis-trans isomerase; Cyclophilin-related protein; Rotamase D

Cyclophilin 40 (CYP-40)
CCC B528
HGNC 9257
MGI 1914988
PubMed 22961554
RGD 1303174
UniProt Q08752
Wiki CYPD

  • Cyclophilin D, which is located in the matrix of mitochondria, is a component of the mitochondrial permeability transition pore. The pore opening raises the permeability of the mitochondrial inner membrane, allows influx of cytosolic molecules into the mitochondrial matrix, increases the matrix volume, and disrupts the mitochondrial outer membrane. As a result, the mitochondria fall into a functional disorder, so the opening of the pore plays an important role in cell death. Cyclophilin D is thought to regulate the opening of the pore because cyclosporin, which binds to CyP-D, inhibits the pore opening.

  • Cyclophilin-40 (CyP40, also CYPD) was identified by Kieffer et al. (1992) as a 40-kD cyclophilin-like protein with PPIase activity. In the bovine uterus, CyP40 is a component of the estrogen receptor complex.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB528Hu01 Recombinant Cyclophilin 40 (CYP-40) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB528Hu01 Polyclonal Antibody to Cyclophilin 40 (CYP-40) WB,IHC,ICC/IF
Assay Kits SEB528Hu ELISA Kit for Cyclophilin 40 (CYP-40) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB528Mu01 Recombinant Cyclophilin 40 (CYP-40) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB528Mu01 Polyclonal Antibody to Cyclophilin 40 (CYP-40) WB; IHC; ICC; IP.
Assay Kits SEB528Mu ELISA Kit for Cyclophilin 40 (CYP-40) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB528Ra01 Recombinant Cyclophilin 40 (CYP-40) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB528Ra01 Polyclonal Antibody to Cyclophilin 40 (CYP-40) WB,IHC
Assay Kits SEB528Ra ELISA Kit for Cyclophilin 40 (CYP-40) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cyclophilin-40, a protein with homology to the P59 component of the steroid receptor complex. Cloning of the cDNA and further characterization."J. Biol. Chem. 268:12303-12310(1993) [PubMed] [Europe PMC] [Abstract]
  2. "The structure and complete nucleotide sequence of the human cyclophilin 40 (PPID) gene."Genomics 35:448-455(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Point mutations in v-Myb disrupt a cyclophilin-catalyzed negative regulatory mechanism."Mol. Cell 1:203-211(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Human cyclophilin 40 is a heat shock protein that exhibits altered intracellular localization following heat shock."Cell Stress Chaperones 6:59-70(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40."J. Mol. Biol. 308:795-806(2001) [PubMed] [Europe PMC] [Abstract]
  9. "A structure-based mutational analysis of cyclophilin 40 identifies key residues in the core tetratricopeptide repeat domain that mediate binding to Hsp90."J. Biol. Chem. 277:40799-40809(2002) [PubMed] [Europe PMC] [Abstract]
  10. "High affinity binding of Hsp90 is triggered by multiple discrete segments of its kinase clients."Biochemistry 42:12550-12561(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70."Cell Stress Chaperones 9:167-181(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Cyclophilin-40 has a cellular role in the aryl hydrocarbon receptor signaling."FEBS Lett. 582:3167-3173(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Multiple cyclophilins involved in different cellular pathways mediate HCV replication."Virology 397:43-55(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Identification of cyclophilin-40-interacting proteins reveals potential cellular function of cyclophilin-40."Anal. Biochem. 410:257-265(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Inhibition of cyclophilins alters lipid trafficking and blocks hepatitis C virus secretion."Virol. J. 8:329-329(2011) [PubMed] [Europe PMC] [Abstract]
  19. "The heat shock protein-90 co-chaperone, Cyclophilin 40, promotes ALK-positive, anaplastic large cell lymphoma viability and its expression is regulated by the NPM-ALK oncoprotein."BMC Cancer 12:229-229(2012) [PubMed] [Europe PMC] [Abstract]
  20. "Cyclophilin 40 alters UVA-induced apoptosis and mitochondrial ROS generation in keratinocytes."Exp. Cell Res. 319:750-760(2013) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]