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Mannose Receptor C Type 1 (MRC1)

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CD206; CLEC13D, CLEC13DL, MRC1L1; C-type lectin domain family 13 member D-like; Macrophage mannose receptor 1-like protein 1

Mannose Receptor C Type 1 (MRC1)
CCC B542
HGNC 7228
MGI 97142
PubMed 11715016
RGD 1309353
UniProt P22897
Wiki MRC1

The mannose receptor found on macrophages and on endothelial cells of the liver is the only known example of a C-type lectin that contains multiple C-type CRDs. One function of the receptor is to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi, so that they can be neutralized by phagocytic engulfment.

Kim et al. characterized the gene for the human macrophage mannose receptor (MRC1) by isolation of clones covering the entire coding region. MRC1 was demonstrated to be divided into 30 exons. The first 3 exons encode the signal sequence, the NH2-terminal cysteine-rich domain, and the fibronectin type II repeat, while the final exon encodes the transmembrane anchor and the cytoplasmic tail.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB542Hu01 Recombinant Mannose Receptor C Type 1 (MRC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB542Hu01 Polyclonal Antibody to Mannose Receptor C Type 1 (MRC1) WB; IHC; ICC; IP.
MAB542Hu22 Monoclonal Antibody to Mannose Receptor C Type 1 (MRC1) WB; IHC; ICC; IP.
Assay Kits SEB542Hu ELISA Kit for Mannose Receptor C Type 1 (MRC1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB542Mu01 Recombinant Mannose Receptor C Type 1 (MRC1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB542Mu02 Recombinant Mannose Receptor C Type 1 (MRC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB542Mu01 Polyclonal Antibody to Mannose Receptor C Type 1 (MRC1) WB; IHC; ICC; IP.
PAB542Mu02 Polyclonal Antibody to Mannose Receptor C Type 1 (MRC1) WB; IHC; ICC; IP.
Assay Kits SEB542Mu ELISA Kit for Mannose Receptor C Type 1 (MRC1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB542Ra01 Recombinant Mannose Receptor C Type 1 (MRC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB542Ra01 Polyclonal Antibody to Mannose Receptor C Type 1 (MRC1) WB; IHC; ICC; IP.
MAB542Ra21 Monoclonal Antibody to Mannose Receptor C Type 1 (MRC1) WB; IHC; ICC; IP.
Assay Kits SEB542Ra ELISA Kit for Mannose Receptor C Type 1 (MRC1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Primary structure of the mannose receptor contains multiple motifs resembling carbohydrate-recognition domains."J. Biol. Chem. 265:12156-12162(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells."J. Exp. Med. 172:1785-1794(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Organization of the gene encoding the human macrophage mannose receptor (MRC1)."Genomics 14:721-727(1992) [PubMed] [Europe PMC] [Abstract]
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  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor."J. Biol. Chem. 275:21539-21548(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility."Hum. Genet. 127:337-348(2010) [PubMed] [Europe PMC] [Abstract]