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Density Enhanced Phosphatase 1 (DEP1)

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CD148; PTPR-J; PTPRJ; HPTPeta; R-PTP-ETA; SCC1; Protein-tyrosine phosphatase eta; Density-enhanced phosphatase 1

Density Enhanced Phosphatase 1 (DEP1)
CCC B545
HGNC 9673
MGI 104574
PubMed 18843023
RGD 3454
UniProt Q12913
Wiki PTPRJ

is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This PTP is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 (PLCG1) and Linker for Activation of T Cells (LAT). This PTP was also found to dephosphorylate PDGF beta receptor, and may be involved in UV-induced signal transduction.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB545Hu01 Recombinant Density Enhanced Phosphatase 1 (DEP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB545Hu01 Polyclonal Antibody to Density Enhanced Phosphatase 1 (DEP1) WB; IHC
MAB545Hu21 Monoclonal Antibody to Density Enhanced Phosphatase 1 (DEP1) WB; IHC; ICC; IP.
Assay Kits SEB545Hu ELISA Kit for Density Enhanced Phosphatase 1 (DEP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB545Mu01 Recombinant Density Enhanced Phosphatase 1 (DEP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB545Mu01 Polyclonal Antibody to Density Enhanced Phosphatase 1 (DEP1) WB,IHC
Assay Kits n/a CLIA Kit for Density Enhanced Phosphatase 1 (DEP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Density Enhanced Phosphatase 1 (DEP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB545Ra01 Recombinant Density Enhanced Phosphatase 1 (DEP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB545Ra01 Polyclonal Antibody to Density Enhanced Phosphatase 1 (DEP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Density Enhanced Phosphatase 1 (DEP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Density Enhanced Phosphatase 1 (DEP1) ELISA Kit Customized Service Offer
  1. "Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density."Proc. Natl. Acad. Sci. U.S.A. 91:9680-9684(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning, characterization, and chromosomal localization of a novel protein-tyrosine phosphatase, HPTP eta."Blood 84:4186-4194(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers."Nat. Genet. 31:295-300(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of novel protein-tyrosine phosphatases in a human leukemia cell line, F-36P."Leukemia 7:742-746(1993) [PubMed] [Europe PMC] [Abstract]
  7. "CD148 is a membrane protein tyrosine phosphatase present in all hematopoietic lineages and is involved in signal transduction on lymphocytes."Blood 91:2800-2809(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Negative regulation of human T cell activation by the receptor-type protein tyrosine phosphatase CD148."J. Immunol. 161:3803-3807(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1."J. Biol. Chem. 275:16219-16226(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation."Mol. Cell. Biol. 21:2393-2403(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Primary sequence determinants responsible for site-selective dephosphorylation of the PDGF beta-receptor by the receptor-like protein tyrosine phosphatase DEP-1."FEBS Lett. 517:27-31(2002) [PubMed] [Europe PMC] [Abstract]
  12. "The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)."Oncogene 21:7067-7076(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1."J. Biol. Chem. 278:5728-5735(2003) [PubMed] [Europe PMC] [Abstract]
  14. "The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling."J. Cell Biol. 162:673-682(2003) [PubMed] [Europe PMC] [Abstract]
  15. "The tyrosine phosphatase DEP-1 induces cytoskeletal rearrangements, aberrant cell-substratum interactions and a reduction in cell proliferation."J. Cell Sci. 117:609-618(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  17. "The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins."Cancer Res. 66:6280-6287(2006) [PubMed] [Europe PMC] [Abstract]
  18. "DEP-1 protein tyrosine phosphatase inhibits proliferation and migration of colon carcinoma cells and is upregulated by protective nutrients."Oncogene 25:6319-6324(2006) [PubMed] [Europe PMC] [Abstract]
  19. "The tyrosine phosphatase CD148 interacts with the p85 regulatory subunit of phosphoinositide 3-kinase."Biochem. J. 413:193-200(2008) [PubMed] [Europe PMC] [Abstract]
  20. "The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis."Blood 113:4942-4954(2009) [PubMed] [Europe PMC] [Abstract]
  21. "An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis."Curr. Biol. 19:1788-1798(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells."J. Biol. Chem. 284:14997-15006(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases."J. Biol. Chem. 284:22048-22058(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  25. "New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival."Mol. Cell. Biol. 29:241-253(2009) [PubMed] [Europe PMC] [Abstract]
  26. "Loss of the protein-tyrosine phosphatase DEP-1/PTPRJ drives meningioma cell motility."Brain Pathol. 21:405-418(2011) [PubMed] [Europe PMC] [Abstract]
  27. "Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as potent negative regulators of PKB/Akt activation in Ras-mutated cancer cells."Biochem. J. 426:65-72(2010) [PubMed] [Europe PMC] [Abstract]
  28. "Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling."J. Biol. Chem. 286:10918-10929(2011) [PubMed] [Europe PMC] [Abstract]
  29. "Solution structure of the fourth FN3 domain of human receptor-type tyrosine-protein phosphatase eta."Submitted (OCT-2006) to the PDB data bank
  30. "The tyrosine phosphatase PTPRJ/DEP-1 genotype affects thyroid carcinogenesis."Oncogene 23:8432-8438(2004) [PubMed] [Europe PMC] [Abstract]