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Large Multifunctional Peptidase 7 (LMP7)

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PSMB8; RING10; PSMB5i, Beta5i; Proteasome(Prosome,Macropain)Subunit,Beta Type 8; Multicatalytic endopeptidase complex subunit C13; Really interesting new gene 10 protein

Large Multifunctional Peptidase 7 (LMP7)
CCC B556
HGNC 9545
MGI 1346527
PubMed 8301122
RGD 3426
UniProt P28062
Wiki PSMB8

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.

  • LMP7 encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB556Hu01 Recombinant Large Multifunctional Peptidase 7 (LMP7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB556Hu01 Polyclonal Antibody to Large Multifunctional Peptidase 7 (LMP7) WB; IHC; ICC; IP.
Assay Kits SEB556Hu ELISA Kit for Large Multifunctional Peptidase 7 (LMP7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB556Mu01 Recombinant Large Multifunctional Peptidase 7 (LMP7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB556Mu01 Polyclonal Antibody to Large Multifunctional Peptidase 7 (LMP7) WB; IHC; ICC; IP.
Assay Kits SEB556Mu ELISA Kit for Large Multifunctional Peptidase 7 (LMP7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB556Ra01 Recombinant Large Multifunctional Peptidase 7 (LMP7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB556Ra01 Polyclonal Antibody to Large Multifunctional Peptidase 7 (LMP7) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Large Multifunctional Peptidase 7 (LMP7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Large Multifunctional Peptidase 7 (LMP7) ELISA Kit Customized Service Offer
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  3. "A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC."Nature 353:357-360(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Alternative exon usage and processing of the major histocompatibility complex-encoded proteasome subunits."J. Biol. Chem. 267:22131-22140(1992) [PubMed] [Europe PMC] [Abstract]
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  10. "Replacement of proteasome subunits X and Y by LMP7 and LMP2 induced by interferon-gamma for acquirement of the functional diversity responsible for antigen processing."FEBS Lett. 343:85-88(1994) [PubMed] [Europe PMC] [Abstract]
  11. "Proteasome subunits X and Y alter peptidase activities in opposite ways to the interferon-gamma-induced subunits LMP2 and LMP7."J. Biol. Chem. 271:17275-17280(1996) [PubMed] [Europe PMC] [Abstract]
  12. "Tumor necrosis factor-alpha induces coordinated changes in major histocompatibility class I presentation pathway, resulting in increased stability of class I complexes at the cell surface."Blood 98:1108-1115(2001) [PubMed] [Europe PMC] [Abstract]
  13. "Bipartite regulation of different components of the MHC class I antigen-processing machinery during dendritic cell maturation."Int. Immunol. 13:1515-1523(2001) [PubMed] [Europe PMC] [Abstract]
  14. "Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits."FEBS Lett. 553:200-204(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Potential effects of tetrodotoxin exposure to human glial cells postulated using microarray approach."Toxicon 44:597-608(2004) [PubMed] [Europe PMC] [Abstract]
  16. "IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome."FEBS Lett. 579:2781-2787(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome."Mol. Immunol. 42:137-141(2005) [PubMed] [Europe PMC] [Abstract]
  18. "IFN-gamma-induced immune adaptation of the proteasome system is an accelerated and transient response."Proc. Natl. Acad. Sci. U.S.A. 102:9241-9246(2005) [PubMed] [Europe PMC] [Abstract]
  19. "Tumor cell lines expressing the proteasome subunit isoform LMP7E1 exhibit immunoproteasome deficiency."Cancer Res. 66:649-652(2006) [PubMed] [Europe PMC] [Abstract]
  20. "Heat shock up-regulates lmp2 and lmp7 and enhances presentation of immunoproteasome-dependent epitopes."J. Immunol. 177:8393-8399(2006) [PubMed] [Europe PMC] [Abstract]
  21. "Genome-wide gene expression differences in Crohn's disease and ulcerative colitis from endoscopic pinch biopsies: insights into distinctive pathogenesis."Inflamm. Bowel Dis. 13:807-821(2007) [PubMed] [Europe PMC] [Abstract]
  22. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  23. "Cardiovascular inflammation and lesion cell apoptosis: a novel connection via the interferon-inducible immunoproteasome."Arterioscler. Thromb. Vasc. Biol. 29:1213-1219(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Herpes simplex virus type I infection of mature dendritic cells leads to reduced LMP7-mRNA-expression levels."Immunobiology 214:861-867(2009) [PubMed] [Europe PMC] [Abstract]
  25. "A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis."Nat. Med. 15:781-787(2009) [PubMed] [Europe PMC] [Abstract]
  26. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  27. "A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans."J. Clin. Invest. 121:4150-4160(2011) [PubMed] [Europe PMC] [Abstract]
  28. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  29. "PSMB8 encoding the beta5i proteasome subunit is mutated in joint contractures, muscle atrophy, microcytic anemia, and panniculitis-induced lipodystrophy syndrome."Am. J. Hum. Genet. 87:866-872(2010) [PubMed] [Europe PMC] [Abstract]
  30. "Mutations in proteasome subunit beta type 8 cause chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature with evidence of genetic and phenotypic heterogeneity."Arthritis Rheum. 64:895-907(2012) [PubMed] [Europe PMC] [Abstract]
  31. "Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome." Proc. Natl. Acad. Sci. U.S.A. 108:14914-14919(2011) [PubMed] [Europe PMC] [Abstract]