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Interferon Omega (IFNw)

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IFN-w; IFNo; Interferon alpha-II-1

Interferon Omega (IFNw)
CCC B569
HGNC 5448
MGI 2448469
PubMed 8098928
UniProt P05000
Wiki IFNW1

IFN-omega is a natural component of human leukocyte interferon. This type 1 interferon protein is called also IFN-alpha II1. It displays a high degree of homology with various IFN-alpha species including positions of the cysteine residues involved in disulfide bonds. However, sequence divergence allows classification as a unique protein family. A related protein is bovine trophoblast protein TP-1.

IFN-omega binds to the same receptors as IFN-alpha and IFN-beta. To date the exact biological activities and the physiological role of this interferon are unknown. The protein has been shown to possess antitumor effects for human tumor xenografts in nude mice.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins APB569Hu01 Active Interferon Omega (IFNw) Cell culture; Activity Assays.
EPB569Hu61 Eukaryotic Interferon Omega (IFNw) Positive Control; Immunogen; SDS-PAGE; WB.
APB569Hu61 Active Interferon Omega (IFNw) Cell culture; Activity Assays.
Antibodies n/a Monoclonal Antibody to Interferon Omega (IFNw) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Omega (IFNw) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Omega (IFNw) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Omega (IFNw) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interferon Omega (IFNw) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interferon Omega (IFNw) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Omega (IFNw) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Omega (IFNw) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Omega (IFNw) ELISA Kit Customized Service Offer
  1. "Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides."Mol. Cell. Biol. 5:768-779(1985) [PubMed] [Europe PMC] [Abstract]
  2. "Human interferon omega 1: isolation of the gene, expression in Chinese hamster ovary cells and characterization of the recombinant protein."Biochim. Biophys. Acta 1089:167-174(1991) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
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  5. "A novel class of human type I interferons."Nucleic Acids Res. 13:4739-4749(1985) [PubMed] [Europe PMC] [Abstract]
  6. "Cloning, sequencing and expression in E. coli of interferon-omega 1 gene."Sci. China, Ser. B, Chem. Life Sci. Earth Sci. 36:1361-1366(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of glycosylated subtypes of interferon-alpha produced by human leukocytes."Biosci. Biotechnol. Biochem. 58:1714-1715(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Purification and characterization of natural human interferon omega 1. Two alternative cleavage sites for the signal peptidase."J. Biol. Chem. 265:9290-9295(1990) [PubMed] [Europe PMC] [Abstract]
  10. "Structural linkage between ligand discrimination and receptor activation by type I interferons."Cell 146:621-632(2011) [PubMed] [Europe PMC] [Abstract]