Mucosae Associated Epithelia Chemokine (MEC)
[Edit]CCL28; SCYA28; Small Inducible Cytokine Subfamily A(Cys-Cys)Member 28; Chemokine C-C-Motif Ligand 28; Small-inducible cytokine A28
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CCL28 is a chemokine. CCL28 regulates the chemotaxis of cells that express the chemokine receptors CCR3 and CCR10. CCL28 is expressed by columnar epithelial cells in the gut, lung, breast and the salivary glands and drives the mucosal homing of T and B lymphocytes that express CCR10, and the migration of eosinophils expressing CCR3.
This chemokine is constitutively expressed in the colon, but its levels can be increased by pro-inflammatory cytokines and certain bacterial products implying a role in effector cell recruitment to sites of epithelial injury. CCL28 has also been implicated in the migration of IgA-expressing cells to the mammary gland, salivary gland, intestine and other mucosal tissues.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB573Hu01 | Recombinant Mucosae Associated Epithelia Chemokine (MEC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APB573Hu01 | Active Mucosae Associated Epithelia Chemokine (MEC) | Cell culture; Activity Assays. | |
| Antibodies | PAB573Hu01 | Polyclonal Antibody to Mucosae Associated Epithelia Chemokine (MEC) | WB; IHC; ICC; IP. |
| MAB573Hu21 | Monoclonal Antibody to Mucosae Associated Epithelia Chemokine (MEC) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB573Hu | ELISA Kit for Mucosae Associated Epithelia Chemokine (MEC) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB573Mu01 | Recombinant Mucosae Associated Epithelia Chemokine (MEC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB573Mu01 | Polyclonal Antibody to Mucosae Associated Epithelia Chemokine (MEC) | WB; IHC; ICC; IP. |
| Assay Kits | SEB573Mu | ELISA Kit for Mucosae Associated Epithelia Chemokine (MEC) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB573Ra01 | Recombinant Mucosae Associated Epithelia Chemokine (MEC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB573Ra01 | Polyclonal Antibody to Mucosae Associated Epithelia Chemokine (MEC) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Mucosae Associated Epithelia Chemokine (MEC) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Mucosae Associated Epithelia Chemokine (MEC) | ELISA Kit Customized Service Offer |
- "Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)."J. Biol. Chem. 275:22313-22323(2000) [PubMed] [Europe PMC] [Abstract]
- "A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues."J. Immunol. 165:2943-2949(2000) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]