≡

Cluster Of Differentiation 32 (CD32)

[Edit]

FcgRII; FCGR2A; FCG2; FCGR2A1; FCGR2; FCGR2B; FCGR2C; Receptor II For The Fc Region Of Immunoglobulin G; Fc Fragment Of IgG, Low Affinity IIa, Receptor; Low affinity immunoglobulin gamma Fc region rec

Cluster Of Differentiation 32 (CD32)
CCC B579
HGNC 3616
MGI 95500
PubMed 9218544
RGD 71069
UniProt P12318
Wiki CD32

CD32 is a surface receptor protein and part of a large population of B cell co-receptors. It has a low-affinity for IgG antibodies and down-regulates antibody production in the presence of IgG. This feedback loops essentially lowers the production of IgG produced by B cells when there is a surplus in the body.Monoclonal antibodies can distinguish between type A and type B.Receptors for the Fc portion of IgG such as FCGR2A play an essential role in the protection of the organism against foreign antigens by removing antigen-antibody complexes from the circulation. Receptors are present on monocytes, macrophages, neutrophils, natural killer (NK) cells, and T and B lymphocytes, and they participate in diverse functions such as phagocytosis of immune complexes and modulation of antibody production by B cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB579Hu01 Recombinant Cluster Of Differentiation 32 (CD32) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB579Hu01 Polyclonal Antibody to Cluster Of Differentiation 32 (CD32) WB; IHC; ICC; IP.
MAB579Hu22 Monoclonal Antibody to Cluster Of Differentiation 32 (CD32) WB; IHC; ICC; IP.
Assay Kits SEB579Hu ELISA Kit for Cluster Of Differentiation 32 (CD32) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cluster Of Differentiation 32 (CD32) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cluster Of Differentiation 32 (CD32) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cluster Of Differentiation 32 (CD32) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 32 (CD32) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 32 (CD32) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB579Ra01 Recombinant Cluster Of Differentiation 32 (CD32) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB579Ra01 Polyclonal Antibody to Cluster Of Differentiation 32 (CD32) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 32 (CD32) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 32 (CD32) ELISA Kit Customized Service Offer
  1. "Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII)."J. Exp. Med. 166:1668-1684(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes."J. Exp. Med. 170:1369-1385(1989) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular cloning of a human immunoglobulin G Fc receptor."Proc. Natl. Acad. Sci. U.S.A. 85:2240-2244(1988) [PubMed] [Europe PMC] [Abstract]
  6. "Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning."EMBO J. 7:1053-1059(1988) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of multiple isoforms of the low-affinity human IgG Fc receptor."Immunogenetics 30:5-12(1989) [PubMed] [Europe PMC] [Abstract]
  8. "Biochemical analysis and crystallisation of Fc gamma RIIa, the low affinity receptor for IgG."Immunol. Lett. 68:17-23(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils."Proc. Natl. Acad. Sci. U.S.A. 90:6305-6309(1993) [PubMed] [Europe PMC] [Abstract]
  10. "Physical and functional association of Src-related protein tyrosine kinases with Fc gamma RII in monocytic THP-1 cells."J. Biol. Chem. 269:8878-8884(1994) [PubMed] [Europe PMC] [Abstract]
  11. "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation."Mol. Cell. Biol. 16:4735-4743(1996) [PubMed] [Europe PMC] [Abstract]
  12. "SHIP-2 inositol phosphatase is inducibly expressed in human monocytes and serves to regulate Fcgamma receptor-mediated signaling."J. Biol. Chem. 278:22657-22663(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of the human leukocyte Fc receptor, Fc gammaRIIa."Nat. Struct. Biol. 6:437-442(1999) [PubMed] [Europe PMC] [Abstract]
  14. "Molecular basis for immune complex recognition: a comparison of Fc-receptor structures."J. Mol. Biol. 309:737-749(2001) [PubMed] [Europe PMC] [Abstract]
  15. "Structural recognition and functional activation of FcgammaR by innate pentraxins."Nature 456:989-992(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans."J. Clin. Invest. 97:1348-1354(1996) [PubMed] [Europe PMC] [Abstract]