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Cytohesin 1 (CYTH1)

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CYT1; B2-1; SEC7; PSCD1; Pleckstrin Homology,Sec7 And Coiled-Coil Domains 1

Cytohesin 1 (CYTH1)
CCC B580
HGNC 9501
MGI 1334257
PubMed 11747824
RGD 620397
UniProt Q15438
Wiki PSCD1

Pleckstrin homology, Sec7 and coiled/coil domains 1 (PSCD1) is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The PSCD1 is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. PSCD1 protein is 83% homologous to PSCD2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB580Hu01 Recombinant Cytohesin 1 (CYTH1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB580Hu01 Polyclonal Antibody to Cytohesin 1 (CYTH1) WB; IHC; FCM
Assay Kits n/a CLIA Kit for Cytohesin 1 (CYTH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytohesin 1 (CYTH1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytohesin 1 (CYTH1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytohesin 1 (CYTH1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytohesin 1 (CYTH1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytohesin 1 (CYTH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytohesin 1 (CYTH1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytohesin 1 (CYTH1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytohesin 1 (CYTH1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytohesin 1 (CYTH1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytohesin 1 (CYTH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytohesin 1 (CYTH1) ELISA Kit Customized Service Offer
  1. "Cloning and sequencing of a human cDNA from cytolytic NK/T cells with homology to yeast SEC7."Biochim. Biophys. Acta 1132:75-78(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors."J. Biol. Chem. 275:3221-3230(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Specific functional interaction of human cytohesin-1 and ADP-ribosylation factor domain protein (ARD1)."J. Biol. Chem. 275:21331-21339(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity."Proc. Natl. Acad. Sci. U.S.A. 99:2625-2629(2002) [PubMed] [Europe PMC] [Abstract]
  8. "The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane."Curr. Biol. 17:711-716(2007) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Solution structure of the cytohesin-1 (B2-1) Sec7 domain and its interaction with the GTPase ADP ribosylation factor 1."Proc. Natl. Acad. Sci. U.S.A. 95:7909-7914(1998) [PubMed] [Europe PMC] [Abstract]