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Cytohesin 2 (CYTH2)

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CYT2; PSCD2; ARNO; CTS18.1; PSCD2L; SEC7L; Sec7p-Like; Pleckstrin Homology,Sec7 And Coiled-Coil Domains 2; ARF exchange factor; ARF nucleotide-binding site opener

Cytohesin 2 (CYTH2)
CCC B583
HGNC 9502
MGI 1334255
PubMed 20525696
RGD 620398
UniProt Q99418
Wiki CYTH2

Pleckstrin homology, Sec7 and coiled/coil domains 2 (PSCD2) is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. PSCD2 exhibits GEP activity in vitro with ARF1, ARF3, and ARF6. PSCD2 protein is 83% homologous to PSCD1. Two transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB583Hu01 Recombinant Cytohesin 2 (CYTH2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB583Hu01 Polyclonal Antibody to Cytohesin 2 (CYTH2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cytohesin 2 (CYTH2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytohesin 2 (CYTH2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytohesin 2 (CYTH2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytohesin 2 (CYTH2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytohesin 2 (CYTH2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytohesin 2 (CYTH2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytohesin 2 (CYTH2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytohesin 2 (CYTH2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytohesin 2 (CYTH2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytohesin 2 (CYTH2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytohesin 2 (CYTH2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytohesin 2 (CYTH2) ELISA Kit Customized Service Offer
  1. "A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains."Nature 384:481-484(1996) [PubMed] [Europe PMC] [Abstract]
  2. "ARNO is a guanine nucleotide exchange factor for ADP-ribosylation factor 6."J. Biol. Chem. 273:23-27(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The calcium-sensing receptor changes cell shape via a beta-arrestin-1 ARNO ARF6 ELMO protein network."J. Cell Sci. 120:2489-2497(2007) [PubMed] [Europe PMC] [Abstract]
  6. "The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane."Curr. Biol. 17:711-716(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Arf6 guanine nucleotide exchange factor cytohesin-2 binds to CCDC120 and is transported along neurites to mediate neurite growth."J. Biol. Chem. 289:33887-33903(2014) [PubMed] [Europe PMC] [Abstract]
  8. "Structure of the guanine nucleotide exchange factor Sec7 domain of human ARNO and analysis of the interaction with ARF GTPase."Cell 92:415-423(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Structure of the Sec7 domain of the Arf exchange factor ARNO."Nature 392:101-105(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor."Nature 426:525-530(2003) [PubMed] [Europe PMC] [Abstract]