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Signal Transducing Adaptor Molecule 1 (STAM1)

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SH3 Domain And ITAM Motif

Signal Transducing Adaptor Molecule 1 (STAM1)
CCC B588
HGNC 11357
MGI 1329014
PubMed 11340172
RGD 1564499
UniProt Q92783
Wiki STAM

Signal transducing adapter molecule 1 is a protein encoded by the STAM gene.This gene was identified by the rapid tyrosine-phosphorylation of its product in response to cytokine stimulation. The encoded protein contains an SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). This protein associates with JAK3 and JAK2 kinases via its ITAM region, and is phosphorylated by the JAK kinases upon cytokine stimulation, which suggests the function of this protein is as an adaptor molecule involved in the downstream signaling of cytokine receptors. HGS/HRS (hepatocyte growth factor-regulated tyrosine kinase substrate) has been found to bind and counteract the function of this protein.Takeshita et al. (1996) used fluorescence in situ hybridization to map the STAM gene to human chromosome 10p14-p13.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB588Hu01 Recombinant Signal Transducing Adaptor Molecule 1 (STAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB588Hu01 Polyclonal Antibody to Signal Transducing Adaptor Molecule 1 (STAM1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Signal Transducing Adaptor Molecule 1 (STAM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Transducing Adaptor Molecule 1 (STAM1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB588Mu01 Recombinant Signal Transducing Adaptor Molecule 1 (STAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB588Mu01 Polyclonal Antibody to Signal Transducing Adaptor Molecule 1 (STAM1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Signal Transducing Adaptor Molecule 1 (STAM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Transducing Adaptor Molecule 1 (STAM1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB588Ra01 Recombinant Signal Transducing Adaptor Molecule 1 (STAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB588Ra01 Polyclonal Antibody to Signal Transducing Adaptor Molecule 1 (STAM1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Signal Transducing Adaptor Molecule 1 (STAM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Transducing Adaptor Molecule 1 (STAM1) ELISA Kit Customized Service Offer
  1. "Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM."Biochem. Biophys. Res. Commun. 225:1035-1039(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway."J. Biol. Chem. 277:1031-1039(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth."J. Biol. Chem. 272:32785-32791(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Possible involvement of a novel STAM-associated molecule 'AMSH' in intracellular signal transduction mediated by cytokines."J. Biol. Chem. 274:19129-19135(1999) [PubMed] [Europe PMC] [Abstract]
  6. "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes."J. Biol. Chem. 278:12513-12521(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Mutation of tyrosine residue 857 in the PDGF beta-receptor affects cell proliferation but not migration."Cell. Signal. 22:1363-1368(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "VHS domains of ESCRT-0 cooperate in high-avidity binding to polyubiquitinated cargo."EMBO J. 29:1045-1054(2010) [PubMed] [Europe PMC] [Abstract]
  13. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]