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Tyrosine Kinase 2 (Tyk2)

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JTK1; Non-Receptor Tyrosine-Protein Kinase TYK2

Tyrosine Kinase 2 (Tyk2)
CCC B595
HGNC 12440
MGI 1929470
PubMed 18683816
UniProt P29597
Wiki TYK2

Non-receptor tyrosine-protein kinase TYK2 is a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity.

Cytokines play pivotal roles in immunity and inflammation by regulating the survival, proliferation, differentiation and function of immune cells as well as cells from other organ systems. Hence, targeting cytokines and their receptors is an effective means of treating such disorders. Type I and II cytokine receptors associate with Janus family kinases (JAKs) to effect intracellular signaling.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB595Hu01 Recombinant Tyrosine Kinase 2 (Tyk2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB595Hu01 Polyclonal Antibody to Tyrosine Kinase 2 (Tyk2) WB; ICC; IHC-P; IHC-F; ELISA.
MAB595Hu22 Monoclonal Antibody to Tyrosine Kinase 2 (Tyk2) WB; IHC; ICC; IP.
MAB595Hu21 Monoclonal Antibody to Tyrosine Kinase 2 (Tyk2) WB; IHC; ICC; IP.
MAB595Hu23 Monoclonal Antibody to Tyrosine Kinase 2 (Tyk2) WB; IHC; ICC; IP.
Assay Kits SEB595Hu ELISA Kit for Tyrosine Kinase 2 (Tyk2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB595Mu01 Recombinant Tyrosine Kinase 2 (Tyk2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB595Mu01 Polyclonal Antibody to Tyrosine Kinase 2 (Tyk2) WB
Assay Kits SEB595Mu ELISA Kit for Tyrosine Kinase 2 (Tyk2) Enzyme-linked immunosorbent assay for Antigen Detection.
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  8. "Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity." Immunity 25:745-755(2006) [PubMed] [Europe PMC] [Abstract]
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  10. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6."J. Mol. Biol. 400:413-433(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]