Chemokine (C-X-C Motif) Ligand 14 (CXCL14)
[Edit]BRAK; SCYB14; BRAK; NJAC; Bolekine; Kec; MIP2-G; MIP2g; BMAC; KS1; Breast And Kidney Expressed Chemokine; Small Inducible Cytokine Subfamily B(Cys-X-Cys)Member 14
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Chemokine (C-X-C motif) ligand 14 (CXCL14) is a small cytokine belonging to the CXC chemokine family that is also known as BRAK (for breast and kidney-expressed chemokine).Mature CXCL14 has many of the conserved features of the CXC chemokine subfamily but has some differences too, such as a shorter N-terminus and five extra amino acids in the region between its third and fourth cysteines.
CXCL14 is constitutively expressed at high levels in many normal tissues, where its cellular source is thought to be fibroblasts.However, it is reduced or absent from most cancer cells.This chemokine is chemotactic for monocytes and can activate these cells in the presence of an inflammatory mediator called prostaglandin-E2 (PGE2).
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB607Hu01 | Recombinant Chemokine (C-X-C Motif) Ligand 14 (CXCL14) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APB607Hu01 | Active Chemokine (C-X-C Motif) Ligand 14 (CXCL14) | Cell culture; Activity Assays. | |
| Antibodies | PAB607Hu01 | Polyclonal Antibody to Chemokine (C-X-C Motif) Ligand 14 (CXCL14) | WB; IHC; ICC; IP. |
| MAB607Hu22 | Monoclonal Antibody to Chemokine (C-X-C Motif) Ligand 14 (CXCL14) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB607Hu | ELISA Kit for Chemokine (C-X-C Motif) Ligand 14 (CXCL14) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCB607Hu | CLIA Kit for Chemokine (C-X-C Motif) Ligand 14 (CXCL14) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB607Mu01 | Recombinant Chemokine (C-X-C Motif) Ligand 14 (CXCL14) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB607Mu02 | Recombinant Chemokine (C-X-C Motif) Ligand 14 (CXCL14) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB607Mu01 | Polyclonal Antibody to Chemokine (C-X-C Motif) Ligand 14 (CXCL14) | WB; IHC; ICC; IP. |
| PAB607Mu02 | Polyclonal Antibody to Chemokine (C-X-C Motif) Ligand 14 (CXCL14) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB607Mu | ELISA Kit for Chemokine (C-X-C Motif) Ligand 14 (CXCL14) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCB607Mu | CLIA Kit for Chemokine (C-X-C Motif) Ligand 14 (CXCL14) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB607Ra01 | Recombinant Chemokine (C-X-C Motif) Ligand 14 (CXCL14) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB607Ra01 | Polyclonal Antibody to Chemokine (C-X-C Motif) Ligand 14 (CXCL14) | WB; IHC; ICC; IP. |
| MAB607Ra21 | Monoclonal Antibody to Chemokine (C-X-C Motif) Ligand 14 (CXCL14) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB607Ra | ELISA Kit for Chemokine (C-X-C Motif) Ligand 14 (CXCL14) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCB607Ra | CLIA Kit for Chemokine (C-X-C Motif) Ligand 14 (CXCL14) | Chemiluminescent immunoassay for Antigen Detection. |
- "In vivo expression of the novel CXC chemokine BRAK in normal and cancerous human tissue."Am. J. Pathol. 156:1937-1950(2000) [PubMed] [Europe PMC] [Abstract]
- "Molecular cloning and characterization of a novel CXC chemokine macrophage inflammatory protein-2 gamma chemoattractant for human neutrophils and dendritic cells."J. Immunol. 165:2588-2595(2000) [PubMed] [Europe PMC] [Abstract]
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
- "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells."Biochem. Biophys. Res. Commun. 255:703-706(1999) [PubMed] [Europe PMC] [Abstract]
- "Structural determinants involved in the regulation of CXCL14/BRAK expression by the 26 S proteasome."J. Mol. Biol. 363:813-822(2006) [PubMed] [Europe PMC] [Abstract]