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Ras GTPase Activating Protein 1 (RASA1)

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Ras-GAP; RasGAP; CM-AVM; CMAVM; GAP; PKWS; RASA; P120GAP; RAS P21 Protein Activator 1; Capillary Malformation-Arteriovenous Malformation

Ras GTPase Activating Protein 1 (RASA1)
CCC B616
HGNC 9871
MGI 97860
PubMed 15917201
RGD 3537
UniProt P20936
Wiki RASA1

RAS p21 protein activator 1 is a 120-kDa cytosolic human protein that provides two principal activities:Inactivation of Ras from its active GTP-bound form to its unactive GDP-bound form by enhancing the endogenous GTPase activity of Ras, via its C-terminal GAP domain Mitogenic signal transmission towards downstream interacting partners through its N-terminal SH2-SH3-SH2 domains. The protein is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB616Hu01 Recombinant Ras GTPase Activating Protein 1 (RASA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB616Hu01 Polyclonal Antibody to Ras GTPase Activating Protein 1 (RASA1) WB; ICC; IHC-P; IHC-F; ELISA.
Assay Kits n/a CLIA Kit for Ras GTPase Activating Protein 1 (RASA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras GTPase Activating Protein 1 (RASA1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras GTPase Activating Protein 1 (RASA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras GTPase Activating Protein 1 (RASA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras GTPase Activating Protein 1 (RASA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras GTPase Activating Protein 1 (RASA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras GTPase Activating Protein 1 (RASA1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras GTPase Activating Protein 1 (RASA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras GTPase Activating Protein 1 (RASA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras GTPase Activating Protein 1 (RASA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras GTPase Activating Protein 1 (RASA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras GTPase Activating Protein 1 (RASA1) ELISA Kit Customized Service Offer
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  26. "RASA1 mutations and associated phenotypes in 68 families with capillary malformation-arteriovenous malformation." Hum. Mutat. 34:1632-1641(2013) [PubMed] [Europe PMC] [Abstract]