Granulocyte Specific Anti-Nuclear Antibody (GSANA)

Antinuclear antibodies (ANA) generally do not show organ specificity and are detectable on a wide range of tissue substrates by the indirect immunofluorescent method. A notable exception is granulocyte-specific (GS) antibody, which reacts with nuclei of mature granulocytes (and monocytes) but not with nuclei of lymphocytes or cells of other tissues.

GS-ANA occur uncommonly in health, and their highest incidence has been found in Felty's syndrome, rheumatoid arthritis, and systemic lupus erythematosus.  The titres of IgD granulocyte-specific antinuclear antibodies varied independently of the titres of IgD and complement-fixing granulocyte-specific antinuclear antibodies, but showed some covariation with granulocyte-specific antinuclear antibodies of the IgA and IgM classes most probably reflecting a broad polyclonal antibody response to phagocyte nuclear antigens in the serologically highly active neutropenic cases.