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Potassium Chloride Cotransporters 3 (KCC3)

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SLC12A6; ACCPN; Solute Carrier Family 12 Member 6,Potassium/Chloride Transporters; Agenesis Of Corpus Callosum And Peripheral Neuropathy; K-Cl cotransporter 3

Potassium Chloride Cotransporters 3 (KCC3)
CCC B628
HGNC 10914
MGI 2135960
PubMed 22423107
UniProt Q9UHW9
Wiki SLC12A6
Solute carrier family 12 member 6 isa member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential.
The predicted 1,099-amino acid SLC12A6 protein contains 12 membrane-spanning segments and 5 N-glycosylation sites. SLC12A6 shares 77% amino acid identity with the ubiquitously expressed KCC1 (SLC12A4) and 73% identity with the brain-restricted KCC2. Northern blot analysis detected strong expression of 9-, 7.5-, and 4.5-kb SLC12A6 transcripts in brain, heart, skeletal muscle, and kidney. Western blot analysis showed expression of a 150-kD SLC12A6 protein that was reduced to 120 kD by glycosidase treatment. Functional analyses confirmed that SLC12A6 is a KCC.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB628Hu01 Recombinant Potassium Chloride Cotransporters 3 (KCC3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB628Hu01 Polyclonal Antibody to Potassium Chloride Cotransporters 3 (KCC3) WB; IHC; ICC; IP.
MAB628Hu22 Monoclonal Antibody to Potassium Chloride Cotransporters 3 (KCC3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Potassium Chloride Cotransporters 3 (KCC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Chloride Cotransporters 3 (KCC3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Chloride Cotransporters 3 (KCC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Chloride Cotransporters 3 (KCC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Chloride Cotransporters 3 (KCC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Chloride Cotransporters 3 (KCC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Chloride Cotransporters 3 (KCC3) ELISA Kit Customized Service Offer
  1. "Molecular cloning and functional characterization of KCC3, a new K-Cl cotransporter."Am. J. Physiol. 277:C1210-C1219(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning, characterization, and chromosomal location of a novel human K+-Cl- cotransporter."J. Biol. Chem. 274:10661-10667(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family."J. Biol. Chem. 274:16355-16362(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum." Nat. Genet. 32:384-392(2002) [PubMed] [Europe PMC] [Abstract]
  5. "NH2-terminal heterogeneity in the KCC3 K+-Cl- cotransporter."Am. J. Physiol. 289:F1246-1261(2005) [PubMed] [Europe PMC] [Abstract]
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  9. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  10. "A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity."J. Biol. Chem. 276:41870-41878(2001) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Similar Effects of all WNK3 Variants upon SLC12 Cotransporters."Am. J. Physiol. 301:C601-C608(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]