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MAP Kinase Activated Protein Kinase 3 (MAPKAPK3)

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MAPKAPK3; 3PK; MK-3; Chromosome 3p kinase; Mitogen Activated Protein Kinase Activated Protein Kinase 3

MAP Kinase Activated Protein Kinase 3 (MAPKAPK3)
CCC B632
HGNC 6888
MGI 2143163
PubMed 19208361
RGD 1304980
UniProt Q16644
Wiki MAPKAPK3

MAPKAPK3 functions as a mitogen-activated protein kinase (MAP kinase)-activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB632Hu01 Recombinant MAP Kinase Activated Protein Kinase 3 (MAPKAPK3) Positive Control; Immunogen; SDS-PAGE; WB.
RPB632Hu02 Recombinant MAP Kinase Activated Protein Kinase 3 (MAPKAPK3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB632Hu01 Polyclonal Antibody to MAP Kinase Activated Protein Kinase 3 (MAPKAPK3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for MAP Kinase Activated Protein Kinase 3 (MAPKAPK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for MAP Kinase Activated Protein Kinase 3 (MAPKAPK3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MAP Kinase Activated Protein Kinase 3 (MAPKAPK3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MAP Kinase Activated Protein Kinase 3 (MAPKAPK3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MAP Kinase Activated Protein Kinase 3 (MAPKAPK3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MAP Kinase Activated Protein Kinase 3 (MAPKAPK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for MAP Kinase Activated Protein Kinase 3 (MAPKAPK3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MAP Kinase Activated Protein Kinase 3 (MAPKAPK3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MAP Kinase Activated Protein Kinase 3 (MAPKAPK3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MAP Kinase Activated Protein Kinase 3 (MAPKAPK3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MAP Kinase Activated Protein Kinase 3 (MAPKAPK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for MAP Kinase Activated Protein Kinase 3 (MAPKAPK3) ELISA Kit Customized Service Offer
  1. "Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase."J. Biol. Chem. 271:8488-8492(1996) [PubMed] [Europe PMC] [Abstract]
  2. "3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region." Mol. Cell. Biol. 16:868-876(1996) [PubMed] [Europe PMC] [Abstract]
  3. Erratum Mol. Cell. Biol. 16:1880-1880(1996)
  4. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress."FEBS Lett. 392:209-214(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation."J. Biol. Chem. 274:18947-18956(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity."J. Biol. Chem. 275:20239-20242(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Mitogen-activated 3p kinase is active in the nucleus."Exp. Cell Res. 299:101-109(2004) [PubMed] [Europe PMC] [Abstract]
  10. "MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1."J. Biol. Chem. 280:5178-5187(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex."Biochem. J. 409:711-722(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "MAPKAP kinases MK2 and MK3 in inflammation: complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin."Biochem. Pharmacol. 80:1915-1920(2010) [PubMed] [Europe PMC] [Abstract]
  14. "MK2 and MK3--a pair of isoenzymes?"Front. Biosci. 13:5511-5521(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  17. "High-resolution crystal structure of human Mapkap kinase 3 in complex with a high affinity ligand."Protein Sci. 19:168-173(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Structure-based lead identification of ATP-competitive MK2 inhibitors."Bioorg. Med. Chem. Lett. 21:3818-3822(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]