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Malonyl Coenzyme A Decarboxylase (MLYCD)

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MCD; Malonyl-CoA decarboxylase, mitochondrial

Malonyl Coenzyme A Decarboxylase (MLYCD)
CCC B664
HGNC 7150
MGI 1928485
PubMed 12955715
RGD 620234
UniProt O95822
Wiki MLYCD

Malonyl-CoA decarboxylase (EC 4.1.1.9) catalyzes the conversion of malonyl-CoA to acetyl-CoA and carbon dioxide. It is thought to be involved in aspects of fatty acid biosynthesis and oxidation.

Malonyl-CoA decarboxylase is found most often in the liver, brain, heart, and skeletal muscle. Gao et al. (1999) searched expressed sequence tag databases to identify human cDNAs with homology to the goose malonyl-CoA decarboxylase cDNA sequence. The 1,479-nucleotide human cDNA sequence is 70% identical to that of goose. FitzPatrick et al. (1999) identified a 2.1-kb human MCD cDNA encoding a 454-amino acid protein that shows 70.3% amino acid identity to goose Mcd.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB664Hu01 Recombinant Malonyl Coenzyme A Decarboxylase (MLYCD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB664Hu01 Polyclonal Antibody to Malonyl Coenzyme A Decarboxylase (MLYCD) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Malonyl Coenzyme A Decarboxylase (MLYCD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Malonyl Coenzyme A Decarboxylase (MLYCD) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB664Mu01 Recombinant Malonyl Coenzyme A Decarboxylase (MLYCD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Malonyl Coenzyme A Decarboxylase (MLYCD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Malonyl Coenzyme A Decarboxylase (MLYCD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Malonyl Coenzyme A Decarboxylase (MLYCD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Malonyl Coenzyme A Decarboxylase (MLYCD) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Malonyl Coenzyme A Decarboxylase (MLYCD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Malonyl Coenzyme A Decarboxylase (MLYCD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Malonyl Coenzyme A Decarboxylase (MLYCD) Polyclonal Antibody Customized Service Offer
Assay Kits SEB664Ra ELISA Kit for Malonyl Coenzyme A Decarboxylase (MLYCD) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The molecular basis of malonyl-CoA decarboxylase deficiency."Am. J. Hum. Genet. 65:318-326(1999) [PubMed] [Europe PMC] [Abstract]
  2. "MCD encodes peroxisomal and cytoplasmic forms of malonyl-CoA decarboxylase and is mutated in malonyl-CoA decarboxylase deficiency."J. Biol. Chem. 274:24461-24468(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and mutational analysis of human malonyl-coenzyme A decarboxylase."J. Lipid Res. 40:178-182(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Expression, purification, and characterization of human malonyl-CoA decarboxylase."Protein Expr. Purif. 34:261-269(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Malonyl CoenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle."Diabetes 57:1508-1516(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities."J. Am. Chem. Soc. 132:3973-3979(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Structural asymmetry and disulphide bridges among subunits modulate the activity of human Malonyl-CoA Decarboxylase."J. Biol. Chem. 288:11907-11919(2013) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations." Structure 21:1182-1192(2013) [PubMed] [Europe PMC] [Abstract]