≡

Interferon Induced Transmembrane Protein 1 (IFITM1)

[Edit]

CD225; IFI17; LEU13; DSPA2a; Interferon-Induced Protein 17; Interferon-Inducible Protein 9-27; Fragilis; Leu-13 antigen; Dispanin subfamily A member 2a

Interferon Induced Transmembrane Protein 1 (IFITM1)
CCC B666
HGNC 5412
MGI 1915963
PubMed 22996292
UniProt P13164
Wiki IFITM1

IFITM1 is a member of the IFITM family which is encoded by IFITM genes. The human IFITM genes locate on chromosome 11 and have four members: IFITM1, IFITM2, IFITM3 and IFITM5. While the mouse Ifitm genes locate on chromosome 7 and 16 and have six members: Ifitm1, Ifitm2, Ifitm3, Ifitm5, Ifitm6 and Ifitm7. IFITM proteins have a short N-terminal and C-terminal domain, two transmembrane domains (TM1 and TM2) and a short cytoplasmic domain. The first transmembrane domain (TM1) and the cytoplasmic domain are conserved among different IFITM proteins in human and mouse. In the absence of interferon stimulation, IFITM proteins can express broadly in tissues and cell lines. In human, ITITM1, IFITM2 and IFITM3 are able to express in different tissues and cells while the expression of IFITM5 is limited to osteoblasts.

 

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interferon Induced Transmembrane Protein 1 (IFITM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interferon Induced Transmembrane Protein 1 (IFITM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Induced Transmembrane Protein 1 (IFITM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Induced Transmembrane Protein 1 (IFITM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Induced Transmembrane Protein 1 (IFITM1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interferon Induced Transmembrane Protein 1 (IFITM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interferon Induced Transmembrane Protein 1 (IFITM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Induced Transmembrane Protein 1 (IFITM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Induced Transmembrane Protein 1 (IFITM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Induced Transmembrane Protein 1 (IFITM1) ELISA Kit Customized Service Offer
  1. "A single DNA response element can confer inducibility by both alpha- and gamma-interferons."Proc. Natl. Acad. Sci. U.S.A. 86:840-844(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth."J. Biol. Chem. 270:23860-23866(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen."J. Immunol. 145:2207-2213(1990) [PubMed] [Europe PMC] [Abstract]
  7. "IFITM1 plays an essential role in the antiproliferative action of interferon-gamma."Oncogene 26:594-603(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Binding of IFITM1 enhances the inhibiting effect of caveolin-1 on ERK activation."Acta Biochim. Biophys. Sin. 41:488-494(2009) [PubMed] [Europe PMC] [Abstract]
  9. "The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus."Cell 139:1243-1254(2009) [PubMed] [Europe PMC] [Abstract]
  10. "The small interferon-induced transmembrane genes and proteins."J. Interferon Cytokine Res. 31:183-197(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells."J. Neurooncol. 103:187-195(2011) [PubMed] [Europe PMC] [Abstract]
  12. "The IFITM proteins inhibit HIV-1 infection."J. Virol. 85:2126-2137(2011) [PubMed] [Europe PMC] [Abstract]
  13. ErratumJ. Virol. 85:4043-4043(2011)
  14. "ISG56 and IFITM1 proteins inhibit hepatitis C virus replication."J. Virol. 85:12881-12889(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus."PLoS Pathog. 7:E1001258-E1001258(2011) [PubMed] [Europe PMC] [Abstract]
  16. "IFITM1 increases osteogenesis through Runx2 in human alveolar-derived bone marrow stromal cells."Bone 51:506-514(2012) [PubMed] [Europe PMC] [Abstract]
  17. "IFITM proteins restrict antibody-dependent enhancement of dengue virus infection."PLoS ONE 7:E34508-E34508(2012) [PubMed] [Europe PMC] [Abstract]
  18. "The dispanins: a novel gene family of ancient origin that contains 14 human members."PLoS ONE 7:E31961-E31961(2012) [PubMed] [Europe PMC] [Abstract]
  19. "A membrane topology model for human interferon inducible transmembrane protein 1."PLoS ONE 9:E104341-E104341(2014) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]