≡

Integrin Alpha M (CD11b)

[Edit]

ITGaM; ITG-AM; CR3A; MAC-1; MAC1A; MO1A; Complement Component 3 Receptor 3 Subunit; Cell surface glycoprotein MAC-1 subunit alpha; Neutrophil adherence receptor

Integrin Alpha M (CD11b)
CCC B685
HGNC 6149
MGI 96607
PubMed 23753600
RGD 2926
UniProt P11215
Wiki ITGAM

Integrin alpha M (ITGAM) is one protein subunit that forms the heterodimeric integrin alpha-M beta-2 (alpha M beta 2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). ITGAM is also known as CR3A, and cluster of differentiation molecule 11B (CD11B). The second chain of alpha beta 2 is the common integrin beta 2 subunit known as CD18, and integrin alpha M beta 2 thus belongs to the beta 2 subfamily (or leukocyte) integrins alpha M beta 2 is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells.It mediates inflammation by regulating leukocyte adhesion and migration and has been implicated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB685Hu01 Recombinant Integrin Alpha M (CD11b) Positive Control; Immunogen; SDS-PAGE; WB.
RPB685Hu02 Recombinant Integrin Alpha M (CD11b) Positive Control; Immunogen; SDS-PAGE; WB.
RPB685Hu03 Recombinant Integrin Alpha M (CD11b) Positive Control; Immunogen; SDS-PAGE; WB.
EPB685Hu61 Eukaryotic Integrin Alpha M (CD11b) Positive Control; Immunogen; SDS-PAGE; WB.
APB685Hu61 Active Integrin Alpha M (CD11b) Cell culture; Activity Assays.
Antibodies PAB685Hu01 Polyclonal Antibody to Integrin Alpha M (CD11b) WB; IHC; ICC; IP.
LAB685Hu71 Biotin-Linked Polyclonal Antibody to Integrin Alpha M (CD11b) WB; IHC; ICC.
PAB685Hu02 Polyclonal Antibody to Integrin Alpha M (CD11b) WB; IHC; ICC; IP.
MAB685Hu26 Monoclonal Antibody to Integrin Alpha M (CD11b) WB; IHC; ICC; IP.
MAB685Hu21 Monoclonal Antibody to Integrin Alpha M (CD11b) WB; IHC; ICC; IP.
Assay Kits SEB685Hu ELISA Kit for Integrin Alpha M (CD11b) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB685Mu01 Recombinant Integrin Alpha M (CD11b) Positive Control; Immunogen; SDS-PAGE; WB.
RPB685Mu02 Recombinant Integrin Alpha M (CD11b) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB685Mu01 Polyclonal Antibody to Integrin Alpha M (CD11b) WB; IHC; ICC; IP.
PAB685Mu02 Polyclonal Antibody to Integrin Alpha M (CD11b) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Integrin Alpha M (CD11b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Alpha M (CD11b) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB685Ra01 Recombinant Integrin Alpha M (CD11b) Positive Control; Immunogen; SDS-PAGE; WB.
RPB685Ra02 Recombinant Integrin Alpha M (CD11b) Positive Control; Immunogen; SDS-PAGE; WB.
RPB685Ra03 Recombinant Integrin Alpha M (CD11b) Positive Control; Immunogen; SDS-PAGE; WB.
RPB685Ra04 Recombinant Integrin Alpha M (CD11b) Positive Control; Immunogen; SDS-PAGE; WB.
RPB685Ra05 Recombinant Integrin Alpha M (CD11b) Positive Control; Immunogen; SDS-PAGE; WB.
RPB685Ra06 Recombinant Integrin Alpha M (CD11b) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB685Ra01 Polyclonal Antibody to Integrin Alpha M (CD11b) WB; IHC; ICC; IP.
PAB685Ra02 Polyclonal Antibody to Integrin Alpha M (CD11b) WB; IHC; ICC; IP.
PAB685Ra03 Polyclonal Antibody to Integrin Alpha M (CD11b) WB; IHC; ICC; IP.
Assay Kits SEB685Ra ELISA Kit for Integrin Alpha M (CD11b) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B."J. Biol. Chem. 263:12403-12411(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of the alpha subunit of human and guinea pig leukocyte adhesion glycoprotein Mo1: chromosomal localization and homology to the alpha subunits of integrins."Proc. Natl. Acad. Sci. U.S.A. 85:2776-2780(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Amino acid sequence of the alpha subunit of human leukocyte adhesion receptor Mo1 (complement receptor type 3)."J. Cell Biol. 106:2153-2158(1988) [PubMed] [Europe PMC] [Abstract]
  4. "Structural analysis of the CD11b gene and phylogenetic analysis of the alpha-integrin gene family demonstrate remarkable conservation of genomic organization and suggest early diversification during evolution."J. Immunol. 150:480-490(1993) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "cDNA sequence for the alpha M subunit of the human neutrophil adherence receptor indicates homology to integrin alpha subunits."Proc. Natl. Acad. Sci. U.S.A. 86:257-261(1989) [PubMed] [Europe PMC] [Abstract]
  7. "The promoter of the CD11b gene directs myeloid-specific and developmentally regulated expression."Proc. Natl. Acad. Sci. U.S.A. 88:10525-10529(1991) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of the myeloid-specific CD11b promoter."Blood 79:865-870(1992) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal sequence of human leukocyte glycoprotein Mo1: conservation across species and homology to platelet IIb/IIIa."Biochim. Biophys. Acta 874:368-371(1986) [PubMed] [Europe PMC] [Abstract]
  10. "The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1."J. Exp. Med. 196:679-691(2002) [PubMed] [Europe PMC] [Abstract]
  11. "JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration."Mol. Biol. Cell 15:3926-3937(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)."Cell 80:631-638(1995) [PubMed] [Europe PMC] [Abstract]
  14. "Two conformations of the integrin A-domain (I-domain): a pathway for activation?"Structure 3:1333-1340(1995) [PubMed] [Europe PMC] [Abstract]
  15. "Cation binding to the integrin CD11b I domain and activation model assessment."Structure 6:923-935(1998) [PubMed] [Europe PMC] [Abstract]
  16. "Experimental support for a beta-propeller domain in integrin alpha-subunits and a calcium binding site on its lower surface."Proc. Natl. Acad. Sci. U.S.A. 95:4870-4875(1998) [PubMed] [Europe PMC] [Abstract]
  17. "A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus."Nat. Genet. 40:152-154(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci." Nat. Genet. 40:204-210(2008) [PubMed] [Europe PMC] [Abstract]