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Kell Protein (KEL)

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CD238; ECE3; Kell Blood Group,Metalloendopeptidase; Metallo-Endopeptidase; Kell blood group glycoprotein

Kell Protein (KEL)
CCC B715
HGNC 6308
MGI 1346053
PubMed 7949106
RGD 1565470
UniProt P23276
Wiki KEL

  • The KEL gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen.

  • The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases. There are several alleles of the gene which creates Kell protein. Two such alleles, K1 (Kell) and K2 (Cellano), are the most common. The kell protein is tightly bound to a second protein, XK, by a disulfide bond. Absence of the XK protein (such as through genetic deletion), leads to marked reduction of the Kell antigens on the red blood cell surface. Absence of the Kell protein (K0), however, does not affect the XK protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB715Hu01 Recombinant Kell Protein (KEL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB715Hu01 Polyclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Kell Protein (KEL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kell Protein (KEL) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB715Mu01 Recombinant Kell Protein (KEL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB715Mu01 Polyclonal Antibody to Kell Protein (KEL) WB,IHC
Assay Kits n/a CLIA Kit for Kell Protein (KEL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kell Protein (KEL) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB715Ra01 Recombinant Kell Protein (KEL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB715Ra01 Polyclonal Antibody to Kell Protein (KEL) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Kell Protein (KEL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kell Protein (KEL) ELISA Kit Customized Service Offer
  1. "Molecular cloning and primary structure of Kell blood group protein."Proc. Natl. Acad. Sci. U.S.A. 88:6353-6357(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Organization of the gene encoding the human Kell blood group protein."Blood 85:1364-1370(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular basis of the K:6,-7 [Js(a+b-)] phenotype in the Kell blood group system."Transfusion 35:822-825(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Association of XK and Kell blood group proteins."J. Biol. Chem. 273:13950-13956(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Proteolytic processing of big endothelin-3 by the kell blood group protein."Blood 94:1440-1450(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Expression of Kell blood group protein in nonerythroid tissues."Blood 96:340-346(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Transcriptional regulation of the KEL gene and Kell protein expression in erythroid and non-erythroid cells."Biochem. J. 356:171-180(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular basis of the Kell (K1) phenotype."Blood 85:912-916(1995) [PubMed] [Europe PMC] [Abstract]
  11. "Point mutations characterize KEL10, the KEL3, KEL4, and KEL21 alleles, and the KEL17 and KEL11 alleles."Transfusion 36:490-494(1996) [PubMed] [Europe PMC] [Abstract]