≡

Rh Blood Group, CcEe Antigens (RHCE)

[Edit]

CD240CE; RHC; RH; RH30A; RHE; RHIXB; RHPI; Rh4; RhVI; RhVIII; DIIIc; RH30; RHCED; RHDVA(TT); RHDel; RHPII; RHXIII; RhDCw; RhII; RhK562-II; RhPI; Rhesus C/E antigens

Rh Blood Group, CcEe Antigens (RHCE)
CCC B717
HGNC 10008
MGI 1202882
PubMed 16231295
UniProt P18577
Wiki RHCE

The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations.

The Rh blood group includes this gene which encodes both the RhC and RhE antigens on a single polypeptide and a second gene which encodes the RhD protein.

The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Alternative splicing of this gene results in four transcript variants encoding four different isoforms.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rh Blood Group, CcEe Antigens (RHCE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rh Blood Group, CcEe Antigens (RHCE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rh Blood Group, CcEe Antigens (RHCE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rh Blood Group, CcEe Antigens (RHCE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rh Blood Group, CcEe Antigens (RHCE) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rh Blood Group, CcEe Antigens (RHCE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rh Blood Group, CcEe Antigens (RHCE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rh Blood Group, CcEe Antigens (RHCE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rh Blood Group, CcEe Antigens (RHCE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rh Blood Group, CcEe Antigens (RHCE) ELISA Kit Customized Service Offer
  1. "cDNA cloning of a 30 kDa erythrocyte membrane protein associated with Rh (Rhesus)-blood-group-antigen expression."Biochem. J. 271:821-825(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and protein structure of a human blood group Rh polypeptide."Proc. Natl. Acad. Sci. U.S.A. 87:6243-6247(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Multiple Rh messenger RNA isoforms are produced by alternative splicing."Blood 80:1074-1078(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Isolation of a new cDNA clone encoding an Rh polypeptide associated with the Rh blood group system."Hum. Genet. 91:157-162(1993) [PubMed] [Europe PMC] [Abstract]
  5. "16Cys encoded by the RHce gene is associated with altered expression of the e antigen and is frequent in the R0 haplotype."Br. J. Haematol. 113:666-671(2001) [PubMed] [Europe PMC] [Abstract]
  6. "E variants found in Japanese and c antigenicity alteration without substitution in the second extracellular loop."Transfusion 41:1408-1412(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Rare RHCE phenotypes in black individuals of Afro-Caribbean origin: identification and transfusion safety."Blood 100:4223-4231(2002) [PubMed] [Europe PMC] [Abstract]
  8. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Organization of the gene (RHCE) encoding the human blood group RhCcEe antigens and characterization of the promoter region."Genomics 19:68-74(1994) [PubMed] [Europe PMC] [Abstract]
  11. "Protein-sequence studies on Rh-related polypeptides suggest the presence of at least two groups of proteins which associate in the human red-cell membrane."Biochem. J. 256:1043-1046(1988) [PubMed] [Europe PMC] [Abstract]
  12. "Determination of the N-terminal sequence of human red cell Rh(D) polypeptide and demonstration that the Rh(D), (c), and (E) antigens are carried by distinct polypeptide chains."Blood 72:661-666(1988) [PubMed] [Europe PMC] [Abstract]
  13. "Intricate combinatorial patterns of exon splicing generate multiple Rh-related isoforms in human erythroid cells."Hum. Genet. 95:657-665(1995) [PubMed] [Europe PMC] [Abstract]
  14. "Identification of two Rh mRNA isoforms expressed in immature erythroblasts."Biochem. Biophys. Res. Commun. 198:1135-1142(1994) [PubMed] [Europe PMC] [Abstract]
  15. "Regarding the size of Rh proteins."Blood 77:411-411(1991) [PubMed] [Europe PMC] [Abstract]
  16. "RHCE represents the ancestral RH position, while RHD is the duplicated gene."Blood 99:2272-2273(2002) [PubMed] [Europe PMC] [Abstract]
  17. "Molecular genetic basis of the human Rhesus blood group system."Nat. Genet. 5:62-65(1993) [PubMed] [Europe PMC] [Abstract]