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Serum/Glucocorticoid Regulated Kinase 2 (SGK2)

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Serine/threonine-protein kinase Sgk2

Serum/Glucocorticoid Regulated Kinase 2 (SGK2)
CCC B722
HGNC 13900
MGI 1351318
PubMed 24204015
RGD 620232
UniProt Q9HBY8
Wiki SGK2

Serum/glucocorticoid regulated kinase 2, is a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids.

This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Two alternate transcripts encoding two different isoforms have been described. SGK2-alpha encodes a protein of 367 amino acids with a calculated molecular mass of about 41 kD. SGK2-beta encodes a protein of 427 amino acids with a calculated molecular mass of about 48 kD. SGK2 shares about 80% sequence identity with SGK1 and SGK3 (SGKL) within the central catalytic domain. Both the N and C termini share much less similarity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB722Hu01 Recombinant Serum/Glucocorticoid Regulated Kinase 2 (SGK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB722Hu01 Polyclonal Antibody to Serum/Glucocorticoid Regulated Kinase 2 (SGK2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Serum/Glucocorticoid Regulated Kinase 2 (SGK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serum/Glucocorticoid Regulated Kinase 2 (SGK2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serum/Glucocorticoid Regulated Kinase 2 (SGK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serum/Glucocorticoid Regulated Kinase 2 (SGK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serum/Glucocorticoid Regulated Kinase 2 (SGK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serum/Glucocorticoid Regulated Kinase 2 (SGK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serum/Glucocorticoid Regulated Kinase 2 (SGK2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serum/Glucocorticoid Regulated Kinase 2 (SGK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serum/Glucocorticoid Regulated Kinase 2 (SGK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serum/Glucocorticoid Regulated Kinase 2 (SGK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serum/Glucocorticoid Regulated Kinase 2 (SGK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serum/Glucocorticoid Regulated Kinase 2 (SGK2) ELISA Kit Customized Service Offer
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  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms."Kidney Blood Press. Res. 25:370-374(2002) [PubMed] [Europe PMC] [Abstract]
  5. "K(+) channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK."Pflugers Arch. 445:60-66(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms."Pflugers Arch. 445:601-606(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC."Pflugers Arch. 445:693-696(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Regulation of the voltage gated K+ channel Kv1.3 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid inducible kinase SGK1."J. Cell. Physiol. 199:194-199(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19."Cell. Physiol. Biochem. 25:723-732(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids."Mol. Biol. Cell 22:3812-3825(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Sgk kinases and their role in epithelial transport."Annu. Rev. Physiol. 68:461-490(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Second AKT: the rise of SGK in cancer signalling."Growth Factors 28:394-408(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]