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Cluster of Differentiation 244 (CD244)

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NKR2B4; 2B4; NAIL; NKR2-B4; Nmrk; SLAMF4; Natural Killer Cell Receptor 2B4; NK cell activation-inducing ligand; Signaling lymphocytic activation molecule 4

Cluster of Differentiation 244 (CD244)
CCC B725
HGNC 18171
MGI 109294
PubMed 15607804
RGD 68400
UniProt Q9BZW8
Wiki NKR2B4

2B4, called also NKR2B4 [natural killer cell receptor 2B4] has been identified originally on mouse NK-cells and subsets of T-cells mediating nonMHC restricted cell killing. Murine NK-cells express two alternatively spliced isoforms, designated 2B4-S and 2B4-L. 2B4-S functions as an activating receptor, whereas 2B4-L is inhibitory. The new designation of this protein is CD244.

The 2B4 protein is expressed on all NK-cells, a subset of CD8(+) T-cells, basophils, mast cells, and monocytes. 2B4 is considered to be an activating receptor because cross-linking of 2B4 on NK-cells with a monoclonal antibody leads to NK-cell activation in vitro. However, 2B4 can also act as an inhibitory signaling receptor for NK-cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cluster of Differentiation 244 (CD244) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cluster of Differentiation 244 (CD244) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cluster of Differentiation 244 (CD244) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cluster of Differentiation 244 (CD244) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster of Differentiation 244 (CD244) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB725Mu01 Recombinant Cluster of Differentiation 244 (CD244) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB725Mu01 Polyclonal Antibody to Cluster of Differentiation 244 (CD244) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster of Differentiation 244 (CD244) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster of Differentiation 244 (CD244) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB725Ra01 Recombinant Cluster of Differentiation 244 (CD244) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB725Ra01 Polyclonal Antibody to Cluster of Differentiation 244 (CD244) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster of Differentiation 244 (CD244) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster of Differentiation 244 (CD244) ELISA Kit Customized Service Offer
  1. "Activating interactions in human NK cell recognition: the role of 2B4-CD48."Eur. J. Immunol. 29:1676-1683(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and biological characterization of NK cell activation-inducing ligand, a counterstructure for CD48."Eur. J. Immunol. 29:3466-3477(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP."J. Immunol. 162:6981-6985(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular characterization of a novel human natural killer cell receptor homologous to mouse 2B4."Tissue Antigens 54:27-34(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Structure of the human natural killer cell receptor 2B4 gene and identification of a novel alternative transcript."Immunogenetics 51:987-992(2000) [PubMed] [Europe PMC] [Abstract]
  6. "X-linked lymphoproliferative disease: 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells."J. Exp. Med. 192:337-346(2000) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Functional role of human NK cell receptor 2B4 (CD244) isoforms."Eur. J. Immunol. 39:1632-1641(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Glycosylation affects ligand binding and function of the activating natural killer cell receptor 2B4 (CD244) protein."J. Biol. Chem. 286:24142-24149(2011) [PubMed] [Europe PMC] [Abstract]