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Immunoglobulin Superfamily, Member 12 (IGSF12)

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CD300A; CMRF35H; CMRF35H9; IRC1; IRC2; IRp60; CD300 antigen-like family member A; CMRF35-like molecule 8; Inhibitory receptor protein 60; NK inhibitory receptor

Immunoglobulin Superfamily, Member 12 (IGSF12)
CCC B731
HGNC 19319
MGI 2443411
PubMed 23640773
UniProt Q9UGN4
Wiki CD300A

CMRF35H is recognized by the same antibody and is distinct from CMRF35 (Green et al., 1998).By screening a cDNA library with a probe to CMRF35, Green et al. (1998) identified a cDNA encoding CMRF35H, which they called CMRF35H9.

The deduced 301-amino acid type I transmembrane protein contains a leader sequence; an extracellular region with a single V-like Ig domain and 2 conserved N-linked glycosylation sites; a membrane proximal region with potential O-linked glycosylation sites and a proline-rich, relatively rigid hinge region; a transmembrane domain; and a long cytoplasmic domain containing 4 potential immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and 2 dileucine motifs, which are associated with endocytosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB731Hu01 Recombinant Immunoglobulin Superfamily, Member 12 (IGSF12) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Immunoglobulin Superfamily, Member 12 (IGSF12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Immunoglobulin Superfamily, Member 12 (IGSF12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Immunoglobulin Superfamily, Member 12 (IGSF12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Immunoglobulin Superfamily, Member 12 (IGSF12) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB731Mu01 Recombinant Immunoglobulin Superfamily, Member 12 (IGSF12) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAB731Mu21 Monoclonal Antibody to Immunoglobulin Superfamily, Member 12 (IGSF12) WB; IHC; ICC; IP.
MAB731Mu22 Monoclonal Antibody to Immunoglobulin Superfamily, Member 12 (IGSF12) WB; IHC; ICC; IP.
MAB731Mu23 Monoclonal Antibody to Immunoglobulin Superfamily, Member 12 (IGSF12) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Immunoglobulin Superfamily, Member 12 (IGSF12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Immunoglobulin Superfamily, Member 12 (IGSF12) ELISA Kit Customized Service Offer
  1. "Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells."Eur. J. Immunol. 29:3148-3159(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The CMRF-35 mAb recognizes a second leukocyte membrane molecule with a domain similar to the poly Ig receptor."Int. Immunol. 10:891-899(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17."Tissue Antigens 55:101-109(2000) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells."J. Immunol. 175:7989-7995(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The crystal structure of IRp60 ectodomain."Submitted (JUN-2007) to the PDB data bank
  8. "Novel immunoglobulin superfamily gene cluster, mapping to a region of human chromosome 17q25, linked to psoriasis susceptibility."Hum. Genet. 112:34-41(2003) [PubMed] [Europe PMC] [Abstract]