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Protein Inhibitor Of Activated STAT 1 (PIAS1)

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GBP; DDXBP1; GU/RH-II; ZMIZ3; Gu-binding protein; Zinc Finger,MIZ-Type Containing 3; DEAD/H(Asp-Glu-Ala-Asp/His)Box Binding Protein 1; RNA helicase II-binding protein

Protein Inhibitor Of Activated STAT 1 (PIAS1)
CCC B736
HGNC 2752
MGI 1913125
PubMed 16135793
RGD 1307843
UniProt O75925
Wiki PIAS1

STAT proteins are latent cytoplasmic transcription factors that become activated by tyrosine phosphorylation in response to cytokine stimulation.

E3 SUMO-protein ligase PIAS1 is  a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB736Hu01 Recombinant Protein Inhibitor Of Activated STAT 1 (PIAS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB736Hu01 Polyclonal Antibody to Protein Inhibitor Of Activated STAT 1 (PIAS1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein Inhibitor Of Activated STAT 1 (PIAS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Inhibitor Of Activated STAT 1 (PIAS1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Inhibitor Of Activated STAT 1 (PIAS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Inhibitor Of Activated STAT 1 (PIAS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Inhibitor Of Activated STAT 1 (PIAS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Inhibitor Of Activated STAT 1 (PIAS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Inhibitor Of Activated STAT 1 (PIAS1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Inhibitor Of Activated STAT 1 (PIAS1) Recombinant Protein Customized Service Offer
Antibodies PAB736Ra01 Polyclonal Antibody to Protein Inhibitor Of Activated STAT 1 (PIAS1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein Inhibitor Of Activated STAT 1 (PIAS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Inhibitor Of Activated STAT 1 (PIAS1) ELISA Kit Customized Service Offer
  1. "Inhibition of Stat1-mediated gene activation by PIAS1."Proc. Natl. Acad. Sci. U.S.A. 95:10626-10631(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1) is a nuclear receptor coregulator expressed in human testis."Mol. Endocrinol. 14:14-26(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site."BMC Genomics 10:518-518(2009) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Cloning and characterization of Gu/RH-II binding protein."Biochem. Biophys. Res. Commun. 234:335-340(1997) [PubMed] [Europe PMC] [Abstract]
  8. "LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1."Biochem. J. 359:485-496(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Involvement of PIAS1 in the sumoylation of tumor suppressor p53."Mol. Cell 8:713-718(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells."Oncogene 20:3880-3887(2001) [PubMed] [Europe PMC] [Abstract]
  11. "SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling."J. Biol. Chem. 277:42981-42986(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes."J. Biol. Chem. 277:50131-50136(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Transcription factor Sp3 is silenced through SUMO modification by PIAS1."EMBO J. 21:5206-5215(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity."Proc. Natl. Acad. Sci. U.S.A. 99:2872-2877(2002) [PubMed] [Europe PMC] [Abstract]
  15. "SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression."Genes Dev. 17:3048-3061(2003) [PubMed] [Europe PMC] [Abstract]
  16. "PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation."J. Biol. Chem. 278:47434-47440(2003) [PubMed] [Europe PMC] [Abstract]
  17. "Repression of the transactivating capacity of the oncoprotein PLAG1 by SUMOylation."J. Biol. Chem. 279:36121-36131(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Sumoylation delimits KLF8 transcriptional activity associated with the cell cycle regulation."J. Biol. Chem. 281:16664-16671(2006) [PubMed] [Europe PMC] [Abstract]
  20. "Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity."Cell 129:903-914(2007) [PubMed] [Europe PMC] [Abstract]
  21. "SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1."Oncogene 26:5866-5876(2007) [PubMed] [Europe PMC] [Abstract]
  22. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  23. "PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling."Genes Dev. 23:118-132(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  26. "SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function."J. Biol. Chem. 286:43793-43808(2011) [PubMed] [Europe PMC] [Abstract]
  27. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  28. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  29. "NMR structure of the N-terminal domain of SUMO ligase PIAS1 and its interaction with tumor suppressor p53 and A/T-rich DNA oligomers."J. Biol. Chem. 279:31455-31461(2004) [PubMed] [Europe PMC] [Abstract]